Rv0501

Tuberculist information
Gene namegalE2
Protein functionPossible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)591.654
Molecular mass(da)41032.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 376
	  		  	1    VSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQNPLINRVIAVDAIAP   60
			  	61   SKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYAPRSGGSAALKELNVMG  120
			  	121  AMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGY  180
			  	181  VRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGA  240
			  	241  LERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELNRE  300
			  	301  QFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPHRVRSWEGRAVGL  360
			  	361  AQRWGSRNPIPWSGLR

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 26 to 256  |  Coverage: 61% Epimerase Range: 25 to 362  |  Coverage: 89% 1 Range: 1 to 376  |  Coverage: 99% 1
Number of amino acids : 376
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF0137026-256
Mtb Structural Proteome models
Model Number1
Model nameRv0501
Template1KEW    APDBCREDO
Template coverage2_361
Template Identity(%)21.6
Model coverage(%)89.6
Normalized DOPE score-0.082

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore10.03
Residue begin1
Residue end376
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0501Gene nameConfidence Score
Rv0502Rv05020.979
Rv0993galU0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-4-keto-6-deoxy-D-glucosePubChem0.9548.286
CPD-663PubChem0.9548.286
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
uridine diphosphate galactosePubChem0.9566.302
pyrophosphatePubChem0.9177.975
UDPGAPubChem0.9580.285
uridine diphosphatePubChem0.9404.161
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
fructosePubChem0.9180.156
uridine triphosphatePubChem0.9484.141
UDP-GlcPubChem0.9566.302
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
UDP-galactosePubChem0.9566.302
sucrosePubChem0.9342.296
H(+)PubChem0.92.01588
glucose-1-phosphatePubChem0.9260.136
UDP-glucosePubChem0.9566.302
galactose-1-phosphatePubChem0.9336.316
deuteriumPubChem0.92.01588