SInCRe - Rv3464

Tuberculist information

Gene name	rmlB
Protein function	dTDP-glucose 4,6-dehydratase RmlB
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3881.84
Molecular mass(da)	37557.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 331

	  		  	1    MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIRLVQGDITD   60
			  	61   AELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRHGVRLHHIST  120
			  	121  DEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGP  180
			  	181  YQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGRIGRTYLISS  240
			  	241  EGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDPSTLYDELCWAPKHTDFEEG  300
			  	301  LRTTIDWYRDNESWWRPLKDATEARYQERGQ

Known structures in the PDB

No Known structures

Number of amino acids : 331

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Epimerase	PF01370	3-239

Mtb Structural Proteome models

Model Number	1
Model name	Rv3464
Template	1OC2 APDB CREDO
Template coverage	6_342
Template Identity(%)	61.5
Model coverage(%)	98.5
Normalized DOPE score	-1.575

Structure Models from Chopin

Model Number	1
Profile	c.2.1.2 - 3.40.50.720 Click for model details
zscore	12.67
Residue begin	1
Residue end	324

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3464	Gene name	Confidence Score
Rv3465	rmlC	0.999
Rv0334	rmlA	0.999
Rv3265c	wbbL1	0.967
Rv1504c	Rv1504c	0.962
Rv1302	rfe	0.952
Rv3266c	rmlD	0.935
Rv3809c	glf	0.928
Rv3809c	glf	0.928
Rv0322	udgA	0.905
Rv0322	udgA	0.905
Rv0322	udgA	0.905

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
dTDP-glucosePubChem	0.995	564.329
deoxythymidine diphosphate-glucosePubChem	0.995	564.329
glucose-1-phosphatePubChem	0.976	260.136
TDP-4-keto-6-deoxy-d-glucosePubChem	0.932	546.314
dTDP-4-amino-4,6-dideoxy-D-glucosePubChem	0.924	547.345
H(+)PubChem	0.917	2.01588
deuteriumPubChem	0.916	2.01588
thymidine triphosphatePubChem	0.91	482.168
dTDP-4-keto-L-rhamnosePubChem	0.9	546.314
dTDP-4-dehydro-L-rhamnosePubChem	0.9	544.298
alpha-ketoglutaratePubChem	0.9	146.098
pyrophosphatePubChem	0.9	177.975
glutamatePubChem	0.9	147.129
protiumPubChem	0.9	2.01576
TDP-FucNPubChem	0.9	546.337
hydroxyl radicalsPubChem	0.9	17.0073
TDP-alpha-GPubChem	0.9	564.329
dTDP-L-rhamnosePubChem	0.887	548.33
thymidine diphosphatePubChem	0.876	402.188
NAD+PubChem	0.826	663.425