Rv3809c

Tuberculist information
Gene nameglf
Protein functionUDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)4272.28
Molecular mass(da)45814.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 399
	  		  	1    MQPMTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVH   60
			  	61   KYGAHLFHTSNKRVWDYVRQFTDFTDYRHRVFAMHNGQAYQFPMGLGLVSQFFGKYFTPE  120
			  	121  QARQLIAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKELPAANITR  180
			  	181  LPVRYTFDNRYFSDTYEGLPTDGYTAWLQNMAADHRIEVRLNTDWFDVRGQLRPGSPAAP  240
			  	241  VVYTGPLDRYFDYAEGRLGWRTLDFEVEVLPIGDFQGTAVMNYNDLDVPYTRIHEFRHFH  300
			  	301  PERDYPTDKTVIMREYSRFAEDDDEPYYPINTEADRALLATYRARAKSETASSKVLFGGR  360
			  	361  LGTYQYLDMHMAIASALNMYDNVLAPHLRDGVPLLQDGA

Known structures in the PDB
PDB ID1V0J
Total residue count1596
Number of chains4
MethodX-RAY
Resolution2.25
PDB ID4FIX
Total residue count1314
Number of chains2
MethodX-RAY
Resolution2.45
PDB ID4FIY
Total residue count1314
Number of chains2
MethodX-RAY
Resolution3.1
1 40 79 118 157 196 235 274 313 352 391 Range: 12 to 81  |  Coverage: 17% NAD_binding_8 Range: 156 to 366  |  Coverage: 52% GLF Range: 4 to 395  |  Coverage: 97% 1 Range: 4 to 394  |  Coverage: 97% 2 Range: 258 to 329  |  Coverage: 17% 1 Range: 11 to 142  |  Coverage: 32% 2 Range: 1 to 399  |  Coverage: 99% 3
Number of amino acids : 399
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_8PF1345012-81
GLFPF03275156-366
Mtb Structural Proteome models
Model Number1
Model nameRv3809c_1v0j_A
Template1V0J    APDBCREDO
Template coverage4_395
Template Identity(%)100.0
Model coverage(%)98.0
Normalized DOPE score-1.422

Model Number2
Model nameRv3809c
Template1V0J    APDBCREDO
Template coverage4_394
Template Identity(%)100.0
Model coverage(%)97.7
Normalized DOPE score-1.178

Structure Models from Chopin
Model Number1
Profiled.16.1.7
Click for model details
zscore20.02
Residue begin258
Residue end329
Model Number2
Profilec.3.1.6 - 3.50.50.60
Click for model details
zscore12.79
Residue begin11
Residue end142
Model Number3
Profilec.1.4.1, c.3.1.1 - 3.20.20.70, 3.40.50.720, 3.50.50.60
Click for model details
zscore11.78
Residue begin1
Residue end399
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3809cGene nameConfidence Score
Rv3465rmlC0.988
Rv3808cglfT20.984
Rv3782glfT10.98
Rv3266crmlD0.977
Rv0334rmlA0.966
Rv3464rmlB0.928
Rv3781rfbE0.926
Rv3806cubiA0.922
Rv3805caftB0.92
Rv3807cRv3807c0.91
Rv1500Rv15000.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-343130NoneNoneNone
CDD-343924NoneNoneNone
CDD-344004NoneNoneNone
CDD-344036NoneNoneNone
CDD-344059NoneNoneNone
CDD-344101NoneNoneNone
CDD-344110NoneNoneNone
CDD-344128NoneNoneNone
CDD-344372NoneNoneNone
CDD-344377NoneNoneNone
CDD-344516NoneNoneNone
CDD-51728NoneNoneNone
CDD-51924NoneNoneNone
CDD-52103NoneNoneNone
CDD-52123NoneNoneNone
CDD-52174NoneNoneNone
CDD-52352NoneNoneNone
CDD-52423NoneNoneNone
CDD-52468NoneNoneNone
CDD-52475NoneNoneNone
CDD-52488NoneNoneNone
CDD-52504NoneNoneNone
CDD-52508NoneNoneNone
CDD-52547NoneNoneNone
CDD-52628NoneNoneNone
CDD-52781NoneNoneNone
CDD-52845NoneNoneNone
CDD-52856NoneNoneNone
CDD-52897NoneNoneNone
CDD-52930NoneNoneNone
CDD-53287NoneNoneNone
CDD-53309NoneNoneNone
CDD-53356NoneNoneNone
CDD-53463NoneNoneNone
CDD-53486NoneNoneNone
CDD-53511NoneNoneNone
CDD-54057NoneNoneNone
CDD-54192NoneNoneNone
CDD-54199NoneNoneNone
CDD-54206NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
GTPase HRas 5P21PharmMapper0 hydroph + 13 HB + 2 pos/neg + 0 aromLink
Antigen peptide transporter 1 1JJ7PharmMapper0 hydroph + 9 HB + 2 pos/neg + 0 aromLink
Ras-related protein Rap-2a 1KAOPharmMapper0 hydroph + 12 HB + 2 pos/neg + 0 aromLink
Sulfotransferase family cytosolic 2B member 1 1Q1ZPharmMapper0 hydroph + 8 HB + 2 pos/neg + 0 aromLink
Pyruvate kinase isozymes R/L 1LIYPharmMapper0 hydroph + 8 HB + 2 pos/neg + 0 aromLink
Sodium channel protein type 10 subunit alpha SEAE_value = 1.37e-49 & MaxTC = 0.53Link
Melatonin receptor 1B SEAE_value = 2.29e-46 & MaxTC = 0.48Link
Melatonin receptor 1A SEAE_value = 3.36e-45 & MaxTC = 0.47Link
Quinone reductase 2 SEAE_value = 1.99e-15 & MaxTC = 0.42Link
Melatonin Agonist SEAE_value = 2.73e-14 & MaxTC = 0.45Link
Coagulation factor XII SEAE_value = 2.9e-11 & MaxTC = 0.37Link
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-glucosePubChem0.998566.302
flavin adenine dinucleotidePubChem0.996785.55
UDP-GalfPubChem0.993566.302
UDP-galactofuranosePubChem0.993566.302
UDP-galactosePubChem0.98566.302
bicinePubChem0.979163.172
uridine diphosphatePubChem0.975404.161
UDP-GalPubChem0.931566.302
uridine diphosphate galactosePubChem0.9566.302
CHEBI:18251PubChem0.9566.302
beta-D-galactosePubChem0.823180.156
phosphonate analogPubChem0.814315.222
GDUPubChem0.784566.302
FADH2 dianionPubChem0.784785.55
1,5-dihydro-FADPubChem0.784787.566
polyuridylic acidPubChem0.753324.181
galactanPubChem0.746532.49
galactosePubChem0.739180.156
beta-D-galactofuranosePubChem0.731180.156
glycerolPubChem0.70792.0938