Tuberculist information
Gene namerfbE
Protein functionProbable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)4227.53
Molecular mass(da)29960.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 273
	  		  	1    VSDPHHPHIQTHNAWVEFPIFDAKSRSLKKAVLGKAGGTIGRNNSNVVVIEALRDITMEL   60
			  	61   NLGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGWAKVTGRVAPVFDLGIGMDPEISGYENI  120
			  	121  IIRGLFLGQTRKQMQAKVDEIAEFTELGEYLSMPLRTYSTGMRVRLAMGVVTSIDPEILL  180
			  	181  LDEGIGAVDADFLRKAQSRLQNLVERSGILVFASHSNEFLARLCKTAIWIDHGVIRLAGG  240
			  	241  IEEVVRAYEGEDAARHVREVLAETQADRQNVQG
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC_tranPF0000553-185
Mtb Structural Proteome models
Model Number1
Model nameRv3781
Template1VPL    APDBCREDO
Template coverage4_238
Template Identity(%)24.1
Model coverage(%)81.7
Normalized DOPE score-0.643

Model Number2
Model nameRv3781.1
Template1JJ7    APDBCREDO
Template coverage494_742
Template Identity(%)20.5
Model coverage(%)94.5
Normalized DOPE score0.506

Structure Models from Chopin
Model Number1
Profilec.37.1.12
Click for model details
zscore21.34
Residue begin1
Residue end273
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3781Gene nameConfidence Score
Rv3783rfbD0.999
Rv3782glfT10.978
Rv3809cglf0.926
Rv3809cglf0.926
Rv3779Rv37790.922
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3781.173oll_EST_A_600PDBCREDO0.6600.1150.6600.001
Rv3781.173oll_EST_B_600PDBCREDO0.6600.1150.6600.001
Rv3781.171a52_EST_A_1PDBCREDO0.6570.1180.6570.001
Rv3781.171a52_EST_B_2PDBCREDO0.6550.1200.6550.001
Rv3781.172ocf_EST_A_596PDBCREDO0.6550.1200.6550.001
Rv3781.173hm1_J3Z_B_1PDBCREDO0.6550.1200.6550.001
Rv3781.171g50_EST_C_2600PDBCREDO0.6540.1210.6540.001
Rv3781.171ere_EST_C_600PDBCREDO0.6530.1210.6530.001
Rv3781.171ere_EST_F_600PDBCREDO0.6530.1210.6530.001
Rv3781.171ere_EST_D_600PDBCREDO0.6520.1220.6520.001
Rv3781.171pcg_EST_A_1PDBCREDO0.6520.1220.6520.001
Rv3781.171qkt_EST_A_600PDBCREDO0.6510.1230.6510.001
Rv3781.172j7x_EST_A_1454PDBCREDO0.6510.1230.6510.001
Rv3781.173lfa_1N1_A_361PDBCREDO0.6630.1120.6360.001
Rv3781.173ols_EST_A_600PDBCREDO0.7180.0680.6330.001
Rv3781.171g50_EST_A_600PDBCREDO0.7170.0680.6330.001
Rv3781.173ols_EST_B_600PDBCREDO0.7160.0690.6320.001
Rv3781.173uud_EST_A_600PDBCREDO0.7110.0720.6280.001
Rv3781.172yja_EST_B_1550PDBCREDO0.7090.0740.6250.001
Rv3781.171mx1_THA_A_1PDBCREDO0.6520.1220.6250.001
Rv3781.171mx1_THA_B_2PDBCREDO0.6790.0980.6240.001
Rv3781.173uud_EST_B_600PDBCREDO0.7060.0760.6230.001
Rv3781.173ads_IMN_B_3PDBCREDO0.6210.1550.6210.001
Rv3781.1203gcs_BAX_A_401PDBCREDO0.6940.0850.6190.001
Rv3781.171gwr_EST_B_600PDBCREDO0.7000.0810.6120.002
Rv3781.171ere_EST_B_600PDBCREDO0.6990.0820.6110.002
Rv3781.171ere_EST_E_600PDBCREDO0.6980.0830.6110.002
Rv3781.171pcg_EST_B_2PDBCREDO0.6980.0830.6110.002
Rv3781.171g50_EST_B_1600PDBCREDO0.6970.0830.6100.002
Rv3781.171ere_EST_A_600PDBCREDO0.6960.0840.6090.002
Rv3781.171qku_EST_A_600PDBCREDO0.6960.0840.6090.002
Rv3781.171qku_EST_B_600PDBCREDO0.6930.0860.6070.002
Rv3781.171qku_EST_C_600PDBCREDO0.6930.0860.6070.002
Rv3781.171gwr_EST_A_600PDBCREDO0.6920.0870.6060.002
Rv3781.1203lzv_017_A_200PDBCREDO0.6020.1760.6020.002
Rv3781.171s9p_DES_B_459PDBCREDO0.7100.0740.6020.002
Rv3781.171mx1_THA_D_4PDBCREDO0.7090.0740.6010.002
Rv3781.171mx1_THA_F_6PDBCREDO0.7080.0750.6000.002
Rv3781.173adx_IMN_B_3PDBCREDO0.6800.0970.6000.002
Rv3781.1201t46_STI_A_3PDBCREDO0.6650.1100.5970.002
Rv3781.171s9p_DES_C_500PDBCREDO0.7030.0780.5960.002
Rv3781.1203gp0_NIL_A_1PDBCREDO0.6820.0950.5960.002
Rv3781.171ya4_CTX_C_3PDBCREDO0.6980.0820.5920.002
Rv3781.171ya4_CTX_B_2PDBCREDO0.6980.0830.5910.002
Rv3781.1204asd_BAX_A_1500PDBCREDO0.6610.1140.5890.003
Rv3781.171r9o_FLP_A_501PDBCREDO0.6720.1040.5880.003
Rv3781.173hm1_J3Z_A_2PDBCREDO0.6720.1040.5880.003
Rv3781.1203heg_BAX_A_1PDBCREDO0.6690.1060.5790.003
Rv3781.172zva_1N1_A_513PDBCREDO0.6830.0950.5790.003
Rv3781.1201n49_RIT_B_301PDBCREDO0.5950.1850.5790.003
Rv3781.1203oez_STI_A_601PDBCREDO0.6120.1650.5780.003
Rv3781.1201n49_RIT_D_401PDBCREDO0.6100.1680.5760.003
Rv3781.171dtl_BEP_A_204PDBCREDO0.6520.1220.5760.003
Rv3781.173bbt_FMM_B_91PDBCREDO0.7340.0570.5750.003
Rv3781.1201c6y_MK1_B_524PDBCREDO0.6230.1520.5740.003
Rv3781.172fum_MIX_B_1539PDBCREDO0.6500.1240.5740.003
Rv3781.172uxp_CLM_B_1211PDBCREDO0.6530.1210.5720.003
Rv3781.1201hsh_MK1_A_401PDBCREDO0.6200.1560.5710.004
Rv3781.1203hec_STI_A_1PDBCREDO0.7230.0640.5700.004
Rv3781.1203spk_TPV_B_100PDBCREDO0.6210.1550.5700.004
Rv3781.1203k5v_STI_A_2PDBCREDO0.5670.2200.5670.004
Rv3781.143glq_RAB_A_602PDBCREDO0.5650.2230.5650.004
Rv3781.1203el0_1UN_A_201PDBCREDO0.5650.2230.5650.004
Rv3781.143glq_RAB_B_602PDBCREDO0.5650.2240.5650.004
Rv3781.171xp0_VDN_A_201PDBCREDO0.5620.2270.5620.004
Rv3781.1201xkk_FMM_A_91PDBCREDO0.6610.1140.5620.004
Rv3781.1201opj_STI_A_3PDBCREDO0.5780.2070.5620.004
Rv3781.1201opj_STI_B_4PDBCREDO0.5780.2070.5620.004
Rv3781.173b2r_VDN_A_1PDBCREDO0.6120.1650.5610.004
Rv3781.173b2r_VDN_B_1PDBCREDO0.6120.1650.5610.004
Rv3781.172uxp_CLM_A_1211PDBCREDO0.6360.1380.5570.004
Rv3781.1203ogp_017_B_200PDBCREDO0.5850.1970.5530.005
Rv3781.1201hsh_MK1_C_402PDBCREDO0.6000.1790.5520.005
Rv3781.172j7y_E3O_A_1454PDBCREDO0.7030.0780.5520.005
Rv3781.1203ms9_STI_B_1PDBCREDO0.5830.2000.5510.005
Rv3781.1202hyy_STI_B_600PDBCREDO0.6360.1380.5500.005
Rv3781.1203mss_STI_B_1PDBCREDO0.5830.2000.5500.005
Rv3781.173erd_DES_A_600PDBCREDO0.7840.0310.5500.005
Rv3781.1201uwj_BAX_A_1723PDBCREDO0.5650.2230.5500.005
Rv3781.1203oez_STI_B_601PDBCREDO0.6970.0830.5500.005
Rv3781.1202hyy_STI_C_600PDBCREDO0.5810.2030.5490.005
Rv3781.1203ogq_AB1_A_200PDBCREDO0.6610.1140.5480.005
Rv3781.1202qxs_RAL_B_600PDBCREDO0.5790.2050.5480.005
Rv3781.1203el9_DR7_A_100PDBCREDO0.5950.1850.5480.005
Rv3781.1201t7j_478_A_200PDBCREDO0.6530.1220.5480.005
Rv3781.1203k5v_STI_B_2PDBCREDO0.5800.2040.5480.005
Rv3781.1201iep_STI_B_202PDBCREDO0.5790.2050.5470.005
Rv3781.1203mss_STI_C_1PDBCREDO0.5790.2050.5470.005
Rv3781.1203pyy_STI_A_3PDBCREDO0.5790.2050.5470.005
Rv3781.171mx1_THA_E_5PDBCREDO0.7510.0470.5470.005
Rv3781.1203ms9_STI_A_1PDBCREDO0.5780.2060.5460.005
Rv3781.1203mss_STI_D_1PDBCREDO0.5780.2060.5460.005
Rv3781.1201iep_STI_A_201PDBCREDO0.5780.2070.5460.005
Rv3781.1203gvu_STI_A_1001PDBCREDO0.5780.2070.5460.005
Rv3781.1203ekq_ROC_A_100PDBCREDO0.5770.2080.5460.005
Rv3781.172uxo_TAC_B_1211PDBCREDO0.6180.1580.5450.005
Rv3781.1203mss_STI_A_1PDBCREDO0.5770.2080.5450.005
Rv3781.171cqp_803_A_311PDBCREDO0.6230.1530.5450.005
Rv3781.171sn0_T44_C_601PDBCREDO0.5950.1850.5450.005
Rv3781.1202hyy_STI_A_600PDBCREDO0.5760.2090.5440.005
Rv3781.173erd_DES_B_800PDBCREDO0.7750.0350.5440.006
Rv3781.1202hyy_STI_D_600PDBCREDO0.5750.2110.5430.006
Rv3781.143n58_ADN_C_500PDBCREDO0.5430.2540.5430.006
Rv3781.1203pyy_STI_B_4PDBCREDO0.5740.2110.5430.006
Rv3781.1203ogp_017_A_200PDBCREDO0.6260.1490.5410.006
Rv3781.171sn5_T3_C_601PDBCREDO0.5640.2240.5410.006
Rv3781.173g5d_1N1_B_1PDBCREDO0.6630.1120.5410.006
Rv3781.1202qxs_RAL_A_600PDBCREDO0.5710.2150.5410.006
Rv3781.141d4f_ADN_A_601PDBCREDO0.5400.2590.5400.006
Rv3781.173vkx_T3_A_301PDBCREDO0.6760.1000.5380.006
Rv3781.1203cs9_NIL_D_600PDBCREDO0.6000.1790.5380.006
Rv3781.1203cs9_NIL_A_600PDBCREDO0.5530.2400.5380.006
Rv3781.1202bpx_MK1_B_902PDBCREDO0.5380.2620.5380.006
Rv3781.1201sh9_RIT_B_301PDBCREDO0.5830.2000.5370.006
Rv3781.143g1u_ADN_B_438PDBCREDO0.5360.2630.5360.006
Rv3781.173clb_TMQ_B_612PDBCREDO0.6120.1650.5360.006
Rv3781.1203cs9_NIL_C_600PDBCREDO0.5960.1830.5350.006
Rv3781.173g5d_1N1_A_1PDBCREDO0.6560.1190.5350.006
Rv3781.173qlg_1N1_B_601PDBCREDO0.6560.1190.5350.006
Rv3781.171s9p_DES_D_600PDBCREDO0.7890.0290.5340.006
Rv3781.171tbf_VIA_A_501PDBCREDO0.6100.1670.5340.006
Rv3781.1202r5q_1UN_B_900PDBCREDO0.5810.2020.5340.007
Rv3781.1202pl0_STI_A_200PDBCREDO0.6160.1600.5330.007
Rv3781.1202r5q_1UN_D_900PDBCREDO0.5810.2020.5330.007
Rv3781.173qlg_1N1_A_601PDBCREDO0.6540.1210.5330.007
Rv3781.173oht_1N1_A_1000PDBCREDO0.7030.0780.5310.007
Rv3781.141v8b_ADN_C_2502PDBCREDO0.5310.2710.5310.007
Rv3781.143g1u_ADN_A_438PDBCREDO0.5300.2720.5300.007
Rv3781.1202oiq_STI_A_1001PDBCREDO0.6130.1640.5300.007
Rv3781.1203rgf_BAX_A_465PDBCREDO0.5450.2510.5300.007
Rv3781.162oa1_ADN_B_2005PDBCREDO0.5580.2330.5290.007
Rv3781.172w8y_NDR_B_1000PDBCREDO0.6230.1530.5280.007
Rv3781.162fn1_SAL_A_506PDBCREDO0.5560.2350.5280.007
Rv3781.1202pym_1UN_A_1001PDBCREDO0.6670.1080.5260.007
Rv3781.1202qak_1UN_A_1001PDBCREDO0.6660.1090.5260.007
Rv3781.1202q64_1UN_B_1001PDBCREDO0.6650.1100.5250.007
Rv3781.162fn1_SAL_B_503PDBCREDO0.5530.2390.5250.007
Rv3781.143n58_ADN_D_500PDBCREDO0.5890.1920.5250.007
Rv3781.1202fxd_DR7_A_102PDBCREDO0.5680.2190.5230.008
Rv3781.1201sgu_MK1_B_2632PDBCREDO0.5540.2390.5230.008
Rv3781.143ce6_ADN_B_500PDBCREDO0.5870.1950.5230.008
Rv3781.143g1u_ADN_C_438PDBCREDO0.5870.1950.5230.008
Rv3781.1202qhc_AB1_B_9001PDBCREDO0.5380.2620.5230.008
Rv3781.171s9p_DES_A_459PDBCREDO0.7720.0370.5230.008
Rv3781.163lps_NOV_A_901PDBCREDO0.5220.2840.5220.008
Rv3781.173sxr_1N1_A_1PDBCREDO0.6150.1610.5220.008
Rv3781.171m17_AQ4_A_999PDBCREDO0.5670.2210.5210.008
Rv3781.1203ufn_ROC_A_401PDBCREDO0.5970.1830.5210.008
Rv3781.1202pyn_1UN_A_1001PDBCREDO0.6600.1140.5210.008
Rv3781.173oht_1N1_B_1000PDBCREDO0.7690.0380.5210.008
Rv3781.143ce6_ADN_D_500PDBCREDO0.5840.1980.5210.008
Rv3781.1202q63_1UN_A_1001PDBCREDO0.6580.1160.5190.008
Rv3781.141d4f_ADN_B_602PDBCREDO0.5830.2000.5190.008
Rv3781.1201hxw_RIT_B_301PDBCREDO0.6100.1680.5190.008
Rv3781.143ce6_ADN_C_500PDBCREDO0.5820.2010.5190.008
Rv3781.1203cs9_NIL_B_600PDBCREDO0.5470.2480.5180.008
Rv3781.162jih_097_A_1001PDBCREDO0.5450.2510.5180.008
Rv3781.143ce6_ADN_A_500PDBCREDO0.5810.2020.5180.008
Rv3781.173kw2_ADN_B_300PDBCREDO0.6110.1670.5180.008
Rv3781.173sxr_1N1_B_2PDBCREDO0.5860.1960.5180.008
Rv3781.173hbb_TMQ_C_613PDBCREDO0.5400.2580.5170.008
Rv3781.171mrl_DOL_A_300PDBCREDO0.5380.2600.5160.009
Rv3781.173clb_TMQ_A_611PDBCREDO0.5380.2610.5150.009
Rv3781.141d4f_ADN_D_604PDBCREDO0.5780.2060.5150.009
Rv3781.1201ohr_1UN_A_201PDBCREDO0.5580.2340.5140.009
Rv3781.171mx1_THA_C_3PDBCREDO0.7570.0440.5130.009
Rv3781.1202o4p_TPV_A_300PDBCREDO0.5580.2330.5120.009
Rv3781.173tmz_06X_A_503PDBCREDO0.5120.3000.5120.009
Rv3781.173ug2_IRE_A_1PDBCREDO0.6740.1020.5120.009
Rv3781.1201uwj_BAX_B_1723PDBCREDO0.5730.2120.5110.009
Rv3781.1202z54_AB1_A_200PDBCREDO0.5570.2350.5110.009
Rv3781.1202o4n_TPV_A_300PDBCREDO0.6070.1710.5090.009
Rv3781.161s14_NOV_A_1300PDBCREDO0.5360.2640.5090.010
Rv3781.1202b7z_MK1_B_200PDBCREDO0.5380.2610.5080.010
Rv3781.143ond_ADN_A_506PDBCREDO0.5070.3080.5070.010
Rv3781.171eqh_FLP_B_1701PDBCREDO0.5060.3090.5060.010
Rv3781.1203s56_ROC_A_201PDBCREDO0.5490.2460.5050.010
Rv3781.141i2w_CFX_A_1300PDBCREDO0.5260.2790.5050.010
Rv3781.173pgh_FLP_D_701PDBCREDO0.5050.3100.5050.010
Rv3781.1201hwk_117_B_1PDBCREDO0.5350.2660.5050.010
Rv3781.1203so9_017_A_100PDBCREDO0.6010.1770.5050.010
Rv3781.1201c6z_ROC_B_505PDBCREDO0.6390.1350.5040.010
Rv3781.1201uwh_BAX_A_1723PDBCREDO0.6010.1780.5040.010
Rv3781.1203nu9_478_A_401PDBCREDO0.5040.3120.5040.010
Rv3781.1202y6o_1N1_A_1892PDBCREDO0.6590.1160.5040.010
Rv3781.171cqe_FLP_B_2650PDBCREDO0.5030.3130.5030.010
Rv3781.171eqh_FLP_A_701PDBCREDO0.5030.3130.5030.010
Rv3781.1201uwh_BAX_B_1723PDBCREDO0.6000.1800.5030.010
Rv3781.1202f80_017_B_301PDBCREDO0.6370.1370.5030.010
Rv3781.173bbt_FMM_D_91PDBCREDO0.7960.0260.5030.010
Rv3781.171cqe_FLP_A_1650PDBCREDO0.5020.3150.5020.011
Rv3781.171uay_ADN_A_1001PDBCREDO0.5740.2120.5020.011
Rv3781.173hbb_TMQ_A_611PDBCREDO0.6010.1770.5020.011
Rv3781.1201rl8_RIT_A_9001PDBCREDO0.6520.1220.5020.011
Rv3781.172gqg_1N1_A_501PDBCREDO0.7150.0700.5020.011
Rv3781.1201d4y_TPV_A_501PDBCREDO0.5980.1820.5020.011
Rv3781.142pou_I7A_A_1000PDBCREDO0.5410.2560.5010.011
Rv3781.143bl1_BL1_A_300PDBCREDO0.5410.2560.5010.011
Rv3781.161s14_NOV_B_2300PDBCREDO0.5280.2760.5010.011
Rv3781.1203b0w_DGX_B_1PDBCREDO0.5000.3180.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions