SInCRe - Rv3783

Tuberculist information

Gene name	rfbD
Protein function	Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	4229.26
Molecular mass(da)	32336.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 280

	  		  	1    MTFMDAQASFQTQSRTLARVRGDLVDGFRRHELWLHLGWQDIKQRYRRSVLGPFWITIAT   60
			  	61   GTTAVAMGGLYSKLFRLELSEHLPYVTLGLIVWNLINAAILDGAEVFVANEGLIKQLPAP  120
			  	121  LSVHVYRLVWRQMIFFAHNIVIYFVIAIIFPKPWSWADLSFLPALALIFLNCVWVSLCFG  180
			  	181  ILATRYRDIGPLLFSVVQLLFFMTPIIWNDETLRRQGAGRWSSIVELNPLLHYLDIVRAP  240
			  	241  LLGAHQELRHWLVVLVLTVVGWMLAAFAMRQYRARVPYWV

Known structures in the PDB

No Known structures

Number of amino acids : 280

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
ABC2_membrane	PF01061	32-242

Mtb Structural Proteome models

Model Number	1
Model name	Rv3783
Template	1WPG APDB CREDO
Template coverage	746_992
Template Identity(%)	7.9
Model coverage(%)	85.4
Normalized DOPE score	1.179

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

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Protein interacting with Rv3783	Gene name	Confidence Score
Rv3781	rfbE	0.999
Rv3782	glfT1	0.977
Rv3779	Rv3779	0.942
Rv3808c	glfT2	0.903

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions