Rv1316c

Tuberculist information
Gene nameogt
Protein functionMethylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)1477.13
Molecular mass(da)17858.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 165
	  		  	1    MIHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTYEPSRTHWTPDPGAFSGAVDQLNAYFAG   60
			  	61   ELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQIGAPGAARAVGLANGHNPI  120
			  	121  AIIVPCHRVIGASGKLTGYGGGINRKRALLELEKSRAPADLTLFD

Known structures in the PDB
PDB ID4BHB
Total residue count165
Number of chains1
MethodX-RAY
Resolution1.8
PDB ID4BHC
Total residue count165
Number of chains1
MethodX-RAY
Resolution2.8
1 17 33 49 65 81 97 113 129 145 161 Range: 1 to 71  |  Coverage: 42% Methyltransf_1N Range: 74 to 157  |  Coverage: 50% DNA_binding_1 Range: 2 to 156  |  Coverage: 93% 1 Range: 1 to 158  |  Coverage: 95% 1 Range: 72 to 159  |  Coverage: 52% 2 Range: 1 to 73  |  Coverage: 43% 3
Number of amino acids : 165
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Methyltransf_1NPF028701-71
DNA_binding_1PF0103574-157
Mtb Structural Proteome models
Model Number1
Model nameRv1316c
Template1SFE    APDBCREDO
Template coverage14_176
Template Identity(%)37.4
Model coverage(%)93.3
Normalized DOPE score-1.091

Structure Models from Chopin
Model Number1
Profilea.4.2.1, c.55.7.1 - 1.10.10.10, 2.30.37.60
Click for model details
zscore42.9
Residue begin1
Residue end158
Model Number2
Profilea.4.2.1
Click for model details
zscore28.78
Residue begin72
Residue end159
Model Number3
Profile2.30.37.60
Click for model details
zscore6.25
Residue begin1
Residue end73
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1316cGene nameConfidence Score
Rv1317calkA0.991
Rv1317calkA0.991
Rv1317calkA0.991
Rv1317calkA0.991
Rv1108cxseA0.956
Rv1108cxseA0.956
Rv1629polA0.95
Rv1629polA0.95
Rv1629polA0.95
Rv1633uvrB0.945
Rv1633uvrB0.945
Rv1633uvrB0.945
Rv1633uvrB0.945
Rv1638uvrA0.921
Rv1420uvrC0.903
Rv1420uvrC0.903
Rv1420uvrC0.903
Rv1420uvrC0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
O6-benzylguaninePubChem0.891241.249
lomeguatribPubChem0.848326.172
O6-methylguaninePubChem0.747165.153
mdGMPPubChem0.733361.248
TMZPubChem0.718128.215
guaninePubChem0.709151.126
5-aza-2'-deoxycytidinePubChem0.705228.205