Rv1108c

Tuberculist information
Gene namexseA
Protein functionProbable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit)
Functional category(tuberculist)information pathways
Gene location(kb)1234.21
Molecular mass(da)44596.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 415
	  		  	1    VTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSL   60
			  	61   TVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLR  120
			  	121  RLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTVASARWPAARFAVRNVAVQG  180
			  	181  PNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGH  240
			  	241  EPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQ  300
			  	301  LRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLA  360
			  	361  RGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVADGALAAVSEGQTNGL

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 9 to 106  |  Coverage: 23% tRNA_anti_2 Range: 128 to 347  |  Coverage: 52% Exonuc_VII_L Range: 9 to 106  |  Coverage: 23% 1
Number of amino acids : 415
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_anti_2PF137429-106
Exonuc_VII_LPF02601128-347
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profileb.40.4.1
Click for model details
zscore5.2
Residue begin9
Residue end106
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1108cGene nameConfidence Score
Rv1107cxseB0.994
Rv3356cfolD0.972
Rv3356cfolD0.972
Rv2533cnusB0.968
Rv1696recN0.959
Rv1316cogt0.956
Rv1316cogt0.956
Rv1633uvrB0.936
Rv1633uvrB0.936
Rv1633uvrB0.936
Rv1633uvrB0.936
Rv0054ssb0.918
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions