Rv2984

Tuberculist information
Gene nameppk1
Protein functionPolyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3339.85
Molecular mass(da)83039.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 742
	  		  	1    MMSNDRKVTEIENSPVTEVRPEEHAWYPDDSALAAPPAATPAAISDQLPSDRYLNRELSW   60
			  	61   LDFNARVLALAADKSMPLLERAKFLAIFASNLDEFYMVRVAGLKRRDEMGLSVRSADGLT  120
			  	121  PREQLGRIGEQTQQLASRHARVFLDSVLPALGEEGIYIVTWADLDQAERDRLSTYFNEQV  180
			  	181  FPVLTPLAVDPAHPFPFVSGLSLNLAVTVRQPEDGTQHFARVKVPDNVDRFVELAAREAS  240
			  	241  EEAAGTEGRTALRFLPMEELIAAFLPVLFPGMEIVEHHAFRITRNADFEVEEDRDEDLLQ  300
			  	301  ALERELARRRFGSPVRLEIADDMTESMLELLLRELDVHPGDVIEVPGLLDLSSLWQIYAV  360
			  	361  DRPTLKDRTFVPATHPAFAERETPKSIFATLREGDVLVHHPYDSFSTSVQRFIEQAAADP  420
			  	421  NVLAIKQTLYRTSGDSPIVRALIDAAEAGKQVVALVEIKARFDEQANIAWARALEQAGVH  480
			  	481  VAYGLVGLKTHCKTALVVRREGPTIRRYCHVGTGNYNSKTARLYEDVGLLTAAPDIGADL  540
			  	541  TDLFNSLTGYSRKLSYRNLLVAPHGIRAGIIDRVEREVAAHRAEGAHNGKGRIRLKMNAL  600
			  	601  VDEQVIDALYRASRAGVRIEVVVRGICALRPGAQGISENIIVRSILGRFLEHSRILHFRA  660
			  	661  IDEFWIGSADMMHRNLDRRVEVMAQVKNPRLTAQLDELFESALDPCTRCWELGPDGQWTA  720
			  	721  SPQEGHSVRDHQESLMERHRSP

Known structures in the PDB
No Known structures
1 75 149 223 297 371 445 519 593 667 741 Range: 52 to 160  |  Coverage: 14% PP_kinase_N Range: 166 to 378  |  Coverage: 28% PP_kinase Range: 386 to 740  |  Coverage: 47% PP_kinase_C Range: 49 to 737  |  Coverage: 92% 1 Range: 48 to 742  |  Coverage: 93% 1 Range: 530 to 742  |  Coverage: 28% 2 Range: 155 to 370  |  Coverage: 28% 3 Range: 48 to 156  |  Coverage: 14% 4 Range: 166 to 320  |  Coverage: 20% 5 Range: 367 to 591  |  Coverage: 30% 6 Range: 391 to 555  |  Coverage: 22% 7
Number of amino acids : 742
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PP_kinase_NPF1308952-160
PP_kinasePF02503166-378
PP_kinase_CPF13090386-740
Mtb Structural Proteome models
Model Number1
Model nameRv2984
Template1XDP    APDBCREDO
Template coverage3_679
Template Identity(%)32.8
Model coverage(%)92.6
Normalized DOPE score-0.481

Structure Models from Chopin
Model Number1
Profilea.7.15.1, d.136.1.4, d.322.1.2 - 3.30.870.10
Click for model details
zscore98.04
Residue begin48
Residue end742
Model Number2
Profiled.136.1.4
Click for model details
zscore36.16
Residue begin530
Residue end742
Model Number3
Profiled.322.1.2
Click for model details
zscore28.65
Residue begin155
Residue end370
Model Number4
Profilea.7.15.1
Click for model details
zscore27.46
Residue begin48
Residue end156
Model Number5
Profile3.30.1840.10
Click for model details
zscore23.15
Residue begin166
Residue end320
Model Number6
Profile3.30.870.10
Click for model details
zscore14.25
Residue begin367
Residue end591
Model Number7
Profiled.136.1.1 - 3.30.870.10
Click for model details
zscore11.06
Residue begin391
Residue end555
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2984Gene nameConfidence Score
Rv0496Rv04960.991
Rv3628ppa0.983
Rv1026Rv10260.983
Rv3232cppk20.954
Rv2445cndkA0.932
Rv0733adk0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.97507.181
pyrophosphatePubChem0.93177.975
adenosine diphosphatePubChem0.9427.201
phosphatePubChem0.8396.9872
magnesiumPubChem0.77624.305
sulfatePubChem0.74996.0626