Rv3232c

Tuberculist information
Gene nameppk2
Protein functionPolyphosphate kinase Ppk2 (polyphosphoric acid kinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3608.87
Molecular mass(da)34092
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 295
	  		  	1    VDIPSVDVSTATNDGASSRAKGHRSAAPGRRKISDAVYQAELFRLQTEFVKLQEWARHSG   60
			  	61   ARLVVIFEGRDGAGKGGAIKRITEYLNPRVARIAALPAPTDRERGQWYYQRYIAHLPAKG  120
			  	121  EIVLFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQMLIDDGILLRKYWFSVSDAEQ  180
			  	181  LRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHTDTPVSPWYVVESDIKKHA  240
			  	241  RLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGNYRRPPRELSTYVDDYVATLIAR

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 32 to 260  |  Coverage: 77% PPK2 Range: 59 to 251  |  Coverage: 65% 1 Range: 32 to 189  |  Coverage: 53% 1
Number of amino acids : 295
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PPK2PF0397632-260
Mtb Structural Proteome models
Model Number1
Model nameRv3232c
Template1UKZ    APDBCREDO
Template coverage13_202
Template Identity(%)12.6
Model coverage(%)65.1
Normalized DOPE score0.003

Structure Models from Chopin
Model Number1
Profilec.37.1.18 - 3.40.50.300
Click for model details
zscore5.32
Residue begin32
Residue end189
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3232cGene nameConfidence Score
Rv2984ppk10.954
Rv2984ppk10.954
Rv2984ppk10.954
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions