SInCRe - Rv1026

Tuberculist information

Gene name	Rv1026
Protein function	Conserved protein
Functional category(tuberculist)	virulence,detoxification and adaptaion
Gene location(kb)	1147.02
Molecular mass(da)	33631.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 319

	  		  	1    VALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIA   60
			  	61   RTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITG  120
			  	121  AEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLH  180
			  	181  SDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAI  240
			  	241  HLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGID  300
			  	301  QLTVSEHDILDGIALSLAG

Known structures in the PDB

No Known structures

Number of amino acids : 319

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Ppx-GppA	PF02541	19-317

Mtb Structural Proteome models

Model Number	1
Model name	Rv1026
Template	1T6C APDB CREDO
Template coverage	8_304
Template Identity(%)	34.0
Model coverage(%)	98.1
Normalized DOPE score	-0.182

Structure Models from Chopin

Model Number	1
Profile	c.55.1.8 - 3.30.420.150, 3.30.420.40 Click for model details
zscore	37.06
Residue begin	2
Residue end	319

Model Number	2
Profile	c.55.1.8 Click for model details
zscore	30.14
Residue begin	2
Residue end	137

Model Number	3
Profile	3.30.420.150 Click for model details
zscore	26.67
Residue begin	134
Residue end	319

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1026	Gene name	Confidence Score
Rv1025	Rv1025	0.989
Rv2984	ppk1	0.983
Rv2984	ppk1	0.983
Rv2984	ppk1	0.983
Rv2583c	relA	0.946
Rv2583c	relA	0.946
Rv2583c	relA	0.946
Rv2583c	relA	0.946

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
guanosine tetraphosphatePubChem	0.964	603.16
pyrophosphatePubChem	0.934	177.975
pppGppPubChem	0.933	683.14
phosphatePubChem	0.928	96.9872
guanosine diphosphatePubChem	0.904	443.201
guanosine triphosphatePubChem	0.903	523.18
deuteriumPubChem	0.9	2.01588
adenosine triphosphatePubChem	0.9	507.181
H(+)PubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
hydroxyl radicalsPubChem	0.9	17.0073
adenosine monophosphatePubChem	0.9	347.221
selenomethioninePubChem	0.769	196.106
SeMetPubChem	0.769	196.106
hydron sulfatePubChem	0.715	196.157
sulfatePubChem	0.715	96.0626