Rv0496

Tuberculist information
Gene nameRv0496
Protein functionConserved hypothetical protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)586.394
Molecular mass(da)34843.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 328
	  		  	1    VVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTIDEFAKIAISSGCAELM   60
			  	61   AFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAVRRWYGWSAGRILNLDI  120
			  	121  GGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLDAELAEPSVT  180
			  	181  VLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTANGLRQLIAFISRMTAVDRA  240
			  	241  ELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALREGLILRKLDSEADGTALIES  300
			  	301  SSVHTSVRAVGGQPADRNAANRSRGSKP

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 17 to 307  |  Coverage: 88% Ppx-GppA Range: 1 to 317  |  Coverage: 96% 1 Range: 1 to 294  |  Coverage: 89% 1 Range: 107 to 296  |  Coverage: 57% 2 Range: 1 to 110  |  Coverage: 33% 3
Number of amino acids : 328
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ppx-GppAPF0254117-307
Mtb Structural Proteome models
Model Number1
Model nameRv0496
Template1U6Z    APDBCREDO
Template coverage26_335
Template Identity(%)20.3
Model coverage(%)96.3
Normalized DOPE score-0.485

Structure Models from Chopin
Model Number1
Profilec.55.1.8 - 3.30.420.150, 3.30.420.40
Click for model details
zscore36.23
Residue begin1
Residue end294
Model Number2
Profile3.30.420.150
Click for model details
zscore21.52
Residue begin107
Residue end296
Model Number3
Profilec.55.1.8
Click for model details
zscore20.35
Residue begin1
Residue end110
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0496Gene nameConfidence Score
Rv2984ppk10.991
Rv2984ppk10.991
Rv2984ppk10.991
Rv0498Rv04980.967
Rv2583crelA0.928
Rv2583crelA0.928
Rv2583crelA0.928
Rv2583crelA0.928
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions