Rv0266c

Tuberculist information
Gene nameoplA
Protein functionProbable 5-oxoprolinase OplA (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)317.525
Molecular mass(da)129618
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1209
	  		  	1    VVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDAAVAGIRALLANGEAGT   60
			  	61   RVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAYQNRPRIFDRRIVLPEMLYER  120
			  	121  VVEVDERVTADGRVLRAPDLEALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQ  180
			  	181  RIGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVRLMFMQSNGG  240
			  	241  LAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVIGFDMGGTSTDVSHYAGEYERVFT  300
			  	301  TQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSAGADPGPACYRGGGPLCVTDA  360
			  	361  NVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRI  420
			  	421  AVANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPPMAGVLSAL  480
			  	481  GIGLADTTAMREQSVEIPLGPAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVHL  540
			  	541  RYEGTDTAIPVQLAEIETMATAFESSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQL  600
			  	601  GDQANDTTGSSETVRIYSNGLWRDAPLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQA  660
			  	661  TMTETGHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATA  720
			  	721  QSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVN  780
			  	781  DPYHGGTHLPDITVITPVFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVL  840
			  	841  FDNWLLAENGRFREAETRRLLTEAPFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFG  900
			  	901  RDVVAAYMRHVQDNAEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTG  960
			  	961  TSAQLDTNFNAPTSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAV 1020
			  	1021 VAGNVETSQAITGALFAALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASV 1080
			  	1081 VQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTL 1140
			  	1141 SGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGP 1200
			  	1201 ASTSARRRR

Known structures in the PDB
No Known structures
1 121 241 361 481 601 721 841 961 1081 1201 Range: 7 to 183  |  Coverage: 14% Hydant_A_N Range: 202 to 491  |  Coverage: 23% Hydantoinase_A Range: 693 to 1209  |  Coverage: 42% Hydantoinase_B Range: 262 to 494  |  Coverage: 19% 1
Number of amino acids : 1209
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Hydant_A_NPF053787-183
Hydantoinase_APF01968202-491
Hydantoinase_BPF02538693-1209
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profile3.30.420.190
Click for model details
zscore9.86
Residue begin262
Residue end494
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0266cGene nameConfidence Score
Rv2394ggtB0.931
Rv0773cggtA0.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamatePubChem0.955147.129
pyroglutamic acidPubChem0.887129.114
buthionine sulfoximinePubChem0.808222.305