Rv2244

Tuberculist information
Gene nameacpM
Protein functionMeromycolate extension acyl carrier protein AcpM
Functional category(tuberculist)lipid metabolism
Gene location(kb)2517.77
Molecular mass(da)12491.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 115
	  		  	1    VPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIP   60
			  	61   DEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDAVANVQARLEAESK

Known structures in the PDB
PDB ID1KLP
Total residue count115
Number of chains1
MethodNMR
ResolutionN/A
1 12 23 34 45 56 67 78 89 100 111 Range: 10 to 77  |  Coverage: 58% PP-binding Range: 1 to 115  |  Coverage: 99% 1 Range: 1 to 96  |  Coverage: 82% 1
Number of amino acids : 115
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PP-bindingPF0055010-77
Mtb Structural Proteome models
Model Number1
Model nameRv2244
Template1KLP    APDBCREDO
Template coverage1_115
Template Identity(%)100.0
Model coverage(%)99.1
Normalized DOPE score-0.333

Structure Models from Chopin
Model Number1
Profilea.28.1.1 - 1.10.1200.10
Click for model details
zscore11.97
Residue begin1
Residue end96
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2244Gene nameConfidence Score
Rv2243fabD0.999
Rv2245kasA0.999
Rv2245kasA0.999
Rv0533cfabH0.999
Rv2246kasB0.999
Rv0533cfabH0.999
Rv2246kasB0.999
Rv0533cfabH0.999
Rv1484inhA0.989
Rv1483fabG10.986
Rv0904caccD30.982
Rv3285accA30.975
Rv3285accA30.975
Rv3285accA30.975
Rv3285accA30.975
Rv0242cfabG40.947
Rv2247accD60.942
Rv2881ccdsA0.942
Rv2965ckdtB0.94
Rv1617pykA0.919
Rv1617pykA0.919
Rv0564cgpdA10.91
Rv0564cgpdA10.91
Rv2982cgpdA20.91
Rv2982cgpdA20.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
malonyl-CoAPubChem0.953853.58
coenzyme APubChem0.938767.534
phosphatePubChem0.90596.9872
bicarbonatePubChem0.962.0248
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
adenosine triphosphatePubChem0.9507.181
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
pyrophosphatePubChem0.9177.975
formatePubChem0.945.0174
Co-APubChem0.9767.534
ara-CTPPubChem0.9483.156
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
glycerol-3-phosphatePubChem0.9172.074
acetyl coenzyme-APubChem0.9809.571
NADP(H)PubChem0.9745.421
adenosine diphosphatePubChem0.9427.201
deuteriumPubChem0.92.01588
malonylcoenzyme APubChem0.9853.58
carbon dioxidePubChem0.944.0095
cytidine triphosphatePubChem0.9483.156
NAD+PubChem0.9663.425
glycerol 1-phosphatePubChem0.9172.074
dihydroxyacetone phosphatePubChem0.9170.058
NADPPubChem0.9744.413
acetyl-CoAPubChem0.9809.571
malonatePubChem0.808104.061
Na(+)PubChem0.78222.9898