Rv2982c

Tuberculist information
Gene namegpdA2
Protein functionProbable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3338
Molecular mass(da)33992
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 334
	  		  	1    MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLP   60
			  	61   PSIHATADAEEALGGASTVLLGVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRM  120
			  	121  SQVIISVTGAEPPQVAVISGPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPY  180
			  	181  TNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATL  240
			  	241  AGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYD  300
			  	301  VEMPLTDAVHRVCHKGLSVDEAITLLLGRRTKPE

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 7 to 165  |  Coverage: 47% NAD_Gly3P_dh_N Range: 183 to 326  |  Coverage: 42% NAD_Gly3P_dh_C Range: 6 to 327  |  Coverage: 96% 1 Range: 1 to 334  |  Coverage: 99% 1 Range: 183 to 326  |  Coverage: 42% 2 Range: 6 to 218  |  Coverage: 63% 3
Number of amino acids : 334
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_Gly3P_dh_NPF012107-165
NAD_Gly3P_dh_CPF07479183-326
Mtb Structural Proteome models
Model Number1
Model nameRv2982c
Template1Z82    APDBCREDO
Template coverage3_312
Template Identity(%)39.4
Model coverage(%)96.1
Normalized DOPE score-0.657

Structure Models from Chopin
Model Number1
Profilea.100.1.6, c.2.1.6 - 1.10.1040.10, 3.40.50.720
Click for model details
zscore62.3
Residue begin1
Residue end334
Model Number2
Profilea.100.1.6
Click for model details
zscore36.68
Residue begin183
Residue end326
Model Number3
Profilec.2.1.6 - 3.40.50.720
Click for model details
zscore9.65
Residue begin6
Residue end218
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2982cGene nameConfidence Score
Rv2244acpM0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerol-3-phosphatePubChem0.977172.074
dihydroxyacetone phosphatePubChem0.97170.058
coenzyme APubChem0.905767.534
deuteriumPubChem0.92.01588
Co-APubChem0.9767.534
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
glycerol 1-phosphatePubChem0.9172.074
glycerolPubChem0.78692.0938
NAD+PubChem0.711663.425