Rv0564c

Tuberculist information
Gene namegpdA1
Protein functionProbable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)654.924
Molecular mass(da)36153.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 341
	  		  	1    MAANKREPKVVVLGGGSWGTTVASICARRGPTLQWVRSAVTAQDINDNHRNSRYLGNDVV   60
			  	61   LSDTLRATTDFTEAANCADVVVMGVPSHGFRGVLVELSKELRPWVPVVSLVKGLEQGTNM  120
			  	121  RMSQIIEEVLPGHPAGILAGPNIAREVAEGYAAAAVLAMPDQHLATRLSAMFRTRRFRVY  180
			  	181  TTDDVVGVETAGALKNVFAIAVGMGYSLGIGENTRALVIARALREMTKLGVAMGGKSETF  240
			  	241  PGLAGLGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMSQVAEGVKAAGVVMEFANEF  300
			  	301  GLNMPIAREVDAVINHGSTVEQAYRGLIAEVPGHEVHGSGF

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 9 to 165  |  Coverage: 45% NAD_Gly3P_dh_N Range: 183 to 327  |  Coverage: 42% NAD_Gly3P_dh_C Range: 8 to 328  |  Coverage: 93% 1 Range: 1 to 341  |  Coverage: 99% 1 Range: 183 to 341  |  Coverage: 46% 2 Range: 9 to 165  |  Coverage: 45% 3 Range: 8 to 218  |  Coverage: 61% 4
Number of amino acids : 341
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_Gly3P_dh_NPF012109-165
NAD_Gly3P_dh_CPF07479183-327
Mtb Structural Proteome models
Model Number1
Model nameRv0564c
Template1Z82    APDBCREDO
Template coverage3_312
Template Identity(%)38.1
Model coverage(%)93.8
Normalized DOPE score-0.626

Structure Models from Chopin
Model Number1
Profilea.100.1.6, c.2.1.6 - 1.10.1040.10, 3.40.50.720
Click for model details
zscore46.71
Residue begin1
Residue end341
Model Number2
Profilea.100.1.6
Click for model details
zscore38.58
Residue begin183
Residue end341
Model Number3
Profilec.2.1.6 - 3.40.50.720
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zscore9.31
Residue begin9
Residue end165
Model Number4
Profilec.2.1.6 - 3.40.50.720
Click for model details
zscore8.26
Residue begin8
Residue end218
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0564cGene nameConfidence Score
Rv2244acpM0.91
Rv2482cplsB20.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerol-3-phosphatePubChem0.971172.074
dihydroxyacetone phosphatePubChem0.964170.058
coenzyme APubChem0.903767.534
Co-APubChem0.9767.534
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
glycerol 1-phosphatePubChem0.9172.074