Rv0770

Tuberculist information
Gene nameRv0770
Protein functionProbable dehydrogenase/reductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)863.256
Molecular mass(da)30445.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 295
	  		  	1    MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGGATAAASVSDV   60
			  	61   AEADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIH  120
			  	121  IVDAPVSGGAAAAAKGELAVMVGADDEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARN  180
			  	181  MLTFVSYAAAAEAQRLAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLR  240
			  	241  PLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 7 to 168  |  Coverage: 54% NAD_binding_2 Range: 170 to 290  |  Coverage: 40% NAD_binding_11 Range: 8 to 293  |  Coverage: 96% 1 Range: 7 to 295  |  Coverage: 97% 1 Range: 167 to 295  |  Coverage: 43% 2 Range: 1 to 93  |  Coverage: 31% 3
Number of amino acids : 295
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_2PF034467-168
NAD_binding_11PF14833170-290
Mtb Structural Proteome models
Model Number1
Model nameRv0770
Template1TEA    APDBCREDO
Template coverage3_281
Template Identity(%)32.3
Model coverage(%)96.6
Normalized DOPE score-0.313

Structure Models from Chopin
Model Number1
Profilea.100.1.1, c.2.1.6
Click for model details
zscore51.31
Residue begin7
Residue end295
Model Number2
Profilea.100.1.1
Click for model details
zscore13.16
Residue begin167
Residue end295
Model Number3
Profilec.5.1.1
Click for model details
zscore8.27
Residue begin1
Residue end93
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0770Gene nameConfidence Score
Rv0753cmmsA0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.913663.425
methylmalonate semialdehydePubChem0.907102.089
1-(4'-hydroxyphenyl)ethanolPubChem0.9138.164
Co-APubChem0.9767.534
bicarbonatePubChem0.962.0248
protiumPubChem0.92.01576
alpha-ketoglutaratePubChem0.9146.098
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
beta-aminoisobutyric acidPubChem0.9103.12
n-propionyl-CoAPubChem0.9823.597
glutamatePubChem0.9147.129
(S)-beta-aminoisobutyratePubChem0.9103.12
deuteriumPubChem0.92.01588
C06002PubChem0.9102.089
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
butyraldehydePubChem0.972.1057
propionyl-CoAPubChem0.9823.597
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
coenzyme APubChem0.9767.534