Rv0241c

Tuberculist information
Gene namehtdX
Protein functionProbable 3-hydroxyacyl-thioester dehydratase HtdX
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)289.812
Molecular mass(da)30162.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 280
	  		  	1    VTQPSGLKNLLRAAAGALPVVPRTDQLPNRTVTVEELPIDPANVAAYAAVTGLRYGNQVP   60
			  	61   LTYPFALTFPSVMSLVTGFDFPFAAMGAIHTENHITQYRPIAVTDAVGVRVRAENLREHR  120
			  	121  RGLLVDLVTNVSVGNDVAWHQVTTFLHQQRTSLSGEPKPPPQKKPKLPPPAAVLRITPAK  180
			  	181  IRRYAAVGGDHNPIHTNPIAAKLFGFPTVIAHGMFTAAAVLANIEARFPDAVRYSVRFAK  240
			  	241  PVLLPATAGLYVAEGDGGWDLTLRNMAKGYPHLTATVRGL

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 27 to 138  |  Coverage: 39% zf-MaoC Range: 158 to 275  |  Coverage: 41% MaoC_dehydratas Range: 24 to 274  |  Coverage: 89% 1
Number of amino acids : 280
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
zf-MaoCPF1345227-138
MaoC_dehydratasPF01575158-275
Mtb Structural Proteome models
Model Number1
Model nameRv0241c
Template1S9C    APDBCREDO
Template coverage12_282
Template Identity(%)19.2
Model coverage(%)89.3
Normalized DOPE score0.509

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
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Protein interacting with Rv0241cGene nameConfidence Score
Rv0242cfabG40.997
Rv0243fadA20.959
Rv0243fadA20.959
Rv0130htdZ0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions