Rv0130

Tuberculist information
Gene namehtdZ
Protein functionProbable 3-hydroxyl-thioester dehydratase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)157.847
Molecular mass(da)16007.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 151
	  		  	1    MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWIHVDPERAAAGPFGTTI   60
			  	61   AHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPVGSRVRATSSLVGVEDLGN  120
			  	121  GTVQATVSTTVEVEGSAKPACVAESIVRYVA

Known structures in the PDB
PDB ID2C2I
Total residue count302
Number of chains2
MethodX-RAY
Resolution1.8
1 16 31 46 61 76 91 106 121 136 151 Range: 9 to 135  |  Coverage: 83% MaoC_dehydratas Range: 2 to 150  |  Coverage: 98% 1 Range: 14 to 149  |  Coverage: 89% 2 Range: 1 to 151  |  Coverage: 99% 1
Number of amino acids : 151
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MaoC_dehydratasPF015759-135
Mtb Structural Proteome models
Model Number1
Model nameRv0130_2c2i_A
Template2C2I    APDBCREDO
Template coverage2_150
Template Identity(%)100.0
Model coverage(%)98.0
Normalized DOPE score-1.249

Model Number2
Model nameRv0130
Template1IQ6    APDBCREDO
Template coverage7_132
Template Identity(%)30.2
Model coverage(%)89.4
Normalized DOPE score-0.257

Structure Models from Chopin
Model Number1
Profiled.38.1.4 - 3.10.129.10
Click for model details
zscore19.26
Residue begin1
Residue end151
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0130Gene nameConfidence Score
Rv0241chtdX0.923
Rv0241chtdX0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
selenomethioninePubChem0.9196.106
SeMetPubChem0.9196.106