SInCRe - Rv1915

Tuberculist information

Gene name	aceAa
Protein function	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2160.46
Molecular mass(da)	40489.8
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 367

	  		  	1    MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVA   60
			  	61   REAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDP  120
			  	121  GPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADAGT  180
			  	181  GHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL  240
			  	241  DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWAS  300
			  	301  RSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWR  360
			  	361  PGRTTRA

Known structures in the PDB

No Known structures

Number of amino acids : 367

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
ICL	PF00463	21-297

Mtb Structural Proteome models

Model Number	1
Model name	Rv1915
Template	1F8M APDB CREDO
Template coverage	8_300
Template Identity(%)	33.1
Model coverage(%)	83.4
Normalized DOPE score	-0.077

Model Number	2
Model name	Rv1915.1
Template	1IGW APDB CREDO
Template coverage	2_386
Template Identity(%)	26.1
Model coverage(%)	95.6
Normalized DOPE score	-0.053

Structure Models from Chopin

Model Number	1
Profile	c.1.12.7 - 3.20.20.60 Click for model details
zscore	28.2
Residue begin	62
Residue end	367

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1915	Gene name	Confidence Score
Rv1916	aceAb	0.999
Rv1837c	glcB	0.924
Rv1475c	acn	0.915
Rv1475c	acn	0.915

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv1915.1	3	2bxg_IBP_B_2001 PDB CREDO	0.670	0.106	0.591	0.002
Rv1915.1	3	1fm6_BRL_D_503 PDB CREDO	0.770	0.037	0.591	0.002
Rv1915.1	3	2prg_BRL_A_1 PDB CREDO	0.755	0.045	0.580	0.003
Rv1915.1	3	1fko_EFZ_A_999 PDB CREDO	0.623	0.152	0.574	0.003
Rv1915.1	3	3cs8_BRL_A_503 PDB CREDO	0.595	0.185	0.572	0.003
Rv1915.1	3	1pbc_BHA_A_396 PDB CREDO	0.706	0.076	0.571	0.004
Rv1915.1	3	2w8y_NDR_B_1000 PDB CREDO	0.593	0.187	0.570	0.004
Rv1915.1	3	3adx_IMN_A_2 PDB CREDO	0.717	0.069	0.570	0.004
Rv1915.1	3	3nt1_NPS_A_5 PDB CREDO	0.570	0.217	0.570	0.004
Rv1915.1	3	3nt1_NPS_B_4 PDB CREDO	0.568	0.219	0.568	0.004
Rv1915.1	3	3lp1_NVP_A_701 PDB CREDO	0.615	0.161	0.567	0.004
Rv1915.1	3	3n8z_FLP_B_1701 PDB CREDO	0.560	0.230	0.560	0.004
Rv1915.1	3	2prg_BRL_B_2 PDB CREDO	0.729	0.060	0.560	0.004
Rv1915.1	3	1a27_EST_A_350 PDB CREDO	0.603	0.175	0.557	0.004
Rv1915.1	3	1xp0_VDN_A_201 PDB CREDO	0.631	0.144	0.557	0.004
Rv1915.1	3	3lp0_NVP_A_701 PDB CREDO	0.605	0.173	0.557	0.004
Rv1915.1	3	2h42_VIA_C_903 PDB CREDO	0.699	0.082	0.556	0.005
Rv1915.1	3	3jwq_VIA_B_901 PDB CREDO	0.698	0.082	0.555	0.005
Rv1915.1	3	1uho_VDN_A_1000 PDB CREDO	0.603	0.176	0.555	0.005
Rv1915.1	5	3bjw_SVR_B_501 PDB CREDO	0.569	0.218	0.554	0.005
Rv1915.1	3	3k2h_LYA_A_514 PDB CREDO	0.599	0.180	0.554	0.005
Rv1915.1	3	1udt_VIA_A_1000 PDB CREDO	0.685	0.093	0.553	0.005
Rv1915.1	3	2uxo_TAC_B_1211 PDB CREDO	0.553	0.239	0.553	0.005
Rv1915.1	3	2ayl_FLP_B_2701 PDB CREDO	0.574	0.212	0.551	0.005
Rv1915.1	3	3ads_IMN_A_2 PDB CREDO	0.743	0.052	0.551	0.005
Rv1915.1	3	1jkh_EFZ_A_999 PDB CREDO	0.598	0.182	0.550	0.005
Rv1915.1	5	3bjw_SVR_H_504 PDB CREDO	0.565	0.224	0.550	0.005
Rv1915.1	5	3bjw_SVR_F_502 PDB CREDO	0.564	0.224	0.550	0.005
Rv1915.1	3	2xn5_FUN_A_1356 PDB CREDO	0.549	0.245	0.549	0.005
Rv1915.1	3	1lw0_NVP_A_999 PDB CREDO	0.571	0.216	0.548	0.005
Rv1915.1	3	3ln1_CEL_D_682 PDB CREDO	0.765	0.040	0.548	0.005
Rv1915.1	3	2ayl_FLP_A_1701 PDB CREDO	0.592	0.189	0.547	0.005
Rv1915.1	3	1gs4_ZK5_A_1918 PDB CREDO	0.686	0.092	0.545	0.005
Rv1915.1	3	1s9p_DES_C_500 PDB CREDO	0.567	0.220	0.545	0.005
Rv1915.1	3	1cqe_FLP_B_2650 PDB CREDO	0.615	0.161	0.543	0.006
Rv1915.1	3	1lwf_NVP_A_999 PDB CREDO	0.590	0.192	0.543	0.006
Rv1915.1	3	1cqe_FLP_A_1650 PDB CREDO	0.614	0.162	0.542	0.006
Rv1915.1	3	1zgy_BRL_A_503 PDB CREDO	0.782	0.032	0.541	0.006
Rv1915.1	3	1jlb_NVP_A_999 PDB CREDO	0.670	0.106	0.541	0.006
Rv1915.1	3	3sxr_1N1_B_2 PDB CREDO	0.540	0.258	0.540	0.006
Rv1915.1	3	3qt0_486_A_4 PDB CREDO	0.753	0.046	0.539	0.006
Rv1915.1	3	1eqh_FLP_B_1701 PDB CREDO	0.611	0.167	0.539	0.006
Rv1915.1	3	2hny_NVP_A_999 PDB CREDO	0.585	0.197	0.539	0.006
Rv1915.1	3	3adx_IMN_B_3 PDB CREDO	0.539	0.260	0.539	0.006
Rv1915.1	5	3bjw_SVR_E_503 PDB CREDO	0.568	0.220	0.539	0.006
Rv1915.1	3	1eqh_FLP_A_701 PDB CREDO	0.610	0.168	0.538	0.006
Rv1915.1	3	1s9p_DES_B_459 PDB CREDO	0.558	0.232	0.536	0.006
Rv1915.1	5	3bjw_SVR_B_512 PDB CREDO	0.551	0.243	0.536	0.006
Rv1915.1	3	1lwc_NVP_A_999 PDB CREDO	0.582	0.201	0.536	0.006
Rv1915.1	3	3b2r_VDN_A_1 PDB CREDO	0.664	0.111	0.536	0.006
Rv1915.1	3	1fk9_EFZ_A_999 PDB CREDO	0.556	0.236	0.534	0.006
Rv1915.1	3	1uof_PNN_A_1312 PDB CREDO	0.534	0.267	0.534	0.006
Rv1915.1	3	3b2r_VDN_B_1 PDB CREDO	0.661	0.114	0.534	0.006
Rv1915.1	3	1fkp_NVP_A_999 PDB CREDO	0.579	0.205	0.533	0.007
Rv1915.1	3	1ot7_IU5_B_1002 PDB CREDO	0.576	0.208	0.532	0.007
Rv1915.1	3	3n8z_FLP_A_701 PDB CREDO	0.598	0.181	0.532	0.007
Rv1915.1	3	2cbr_A80_A_201 PDB CREDO	0.621	0.155	0.532	0.007
Rv1915.1	3	3qip_NVP_A_561 PDB CREDO	0.575	0.210	0.530	0.007
Rv1915.1	3	3h0a_9RA_A_500 PDB CREDO	0.739	0.054	0.529	0.007
Rv1915.1	3	3sxr_1N1_A_1 PDB CREDO	0.550	0.244	0.529	0.007
Rv1915.1	3	3hvt_NVP_A_557 PDB CREDO	0.571	0.216	0.526	0.007
Rv1915.1	3	1hk1_T44_A_3001 PDB CREDO	0.570	0.217	0.525	0.007
Rv1915.1	3	2iyf_ERY_A_1400 PDB CREDO	0.523	0.283	0.523	0.008
Rv1915.1	3	1fm6_BRL_X_504 PDB CREDO	0.833	0.014	0.523	0.008
Rv1915.1	3	2h42_VIA_B_902 PDB CREDO	0.657	0.118	0.523	0.008
Rv1915.1	3	3pgh_FLP_D_701 PDB CREDO	0.592	0.189	0.522	0.008
Rv1915.1	3	3nrr_D16_A_520 PDB CREDO	0.617	0.159	0.522	0.008
Rv1915.1	5	3bjw_SVR_E_510 PDB CREDO	0.578	0.207	0.522	0.008
Rv1915.1	5	3bjw_SVR_H_511 PDB CREDO	0.577	0.208	0.521	0.008
Rv1915.1	3	1ya3_STR_C_3001 PDB CREDO	0.629	0.146	0.519	0.008
Rv1915.1	3	1fds_EST_A_350 PDB CREDO	0.588	0.193	0.519	0.008
Rv1915.1	3	1hk2_T44_A_3003 PDB CREDO	0.564	0.225	0.519	0.008
Rv1915.1	3	1jip_KTN_A_801 PDB CREDO	0.541	0.257	0.519	0.008
Rv1915.1	3	1s1u_NVP_A_999 PDB CREDO	0.563	0.226	0.518	0.008
Rv1915.1	3	3axz_ADN_A_401 PDB CREDO	0.614	0.163	0.518	0.008
Rv1915.1	5	3bjw_SVR_F_509 PDB CREDO	0.573	0.212	0.518	0.008
Rv1915.1	3	2bxc_P1Z_A_2001 PDB CREDO	0.539	0.259	0.518	0.008
Rv1915.1	3	4cox_IMN_B_701 PDB CREDO	0.586	0.196	0.518	0.008
Rv1915.1	3	1ki3_PE2_A_1 PDB CREDO	0.538	0.261	0.517	0.008
Rv1915.1	3	4cox_IMN_C_701 PDB CREDO	0.586	0.197	0.517	0.008
Rv1915.1	5	1uwj_BAX_A_1723 PDB CREDO	0.608	0.169	0.516	0.009
Rv1915.1	3	4cox_IMN_A_701 PDB CREDO	0.585	0.198	0.516	0.009
Rv1915.1	3	3aod_RFP_C_2002 PDB CREDO	0.624	0.151	0.515	0.009
Rv1915.1	3	3nrr_D16_B_520 PDB CREDO	0.692	0.087	0.513	0.009
Rv1915.1	3	1mx1_THA_F_6 PDB CREDO	0.534	0.267	0.513	0.009
Rv1915.1	3	2h77_T3_A_1 PDB CREDO	0.740	0.053	0.512	0.009
Rv1915.1	3	3ln1_CEL_C_682 PDB CREDO	0.791	0.028	0.512	0.009
Rv1915.1	3	3ln1_CEL_B_682 PDB CREDO	0.789	0.029	0.511	0.009
Rv1915.1	3	2trt_TAC_A_222 PDB CREDO	0.511	0.301	0.511	0.009
Rv1915.1	3	3ln1_CEL_A_682 PDB CREDO	0.789	0.029	0.511	0.009
Rv1915.1	3	1mx1_THA_D_4 PDB CREDO	0.531	0.271	0.511	0.009
Rv1915.1	3	1fj8_CER_C_500 PDB CREDO	0.554	0.238	0.510	0.009
Rv1915.1	3	1jlf_NVP_A_999 PDB CREDO	0.630	0.145	0.509	0.009
Rv1915.1	3	2x7h_PFN_A_1372 PDB CREDO	0.691	0.088	0.509	0.009
Rv1915.1	3	3ols_EST_B_600 PDB CREDO	0.509	0.305	0.509	0.010
Rv1915.1	3	1z9y_FUN_A_500 PDB CREDO	0.571	0.215	0.508	0.010
Rv1915.1	3	1fj8_CER_A_500 PDB CREDO	0.551	0.242	0.508	0.010
Rv1915.1	3	1fj8_CER_D_500 PDB CREDO	0.551	0.242	0.508	0.010
Rv1915.1	3	3qgz_ADN_A_127 PDB CREDO	0.615	0.162	0.507	0.010
Rv1915.1	3	2o7o_DXT_A_222 PDB CREDO	0.507	0.308	0.507	0.010
Rv1915.1	3	3jwq_VIA_D_901 PDB CREDO	0.708	0.075	0.507	0.010
Rv1915.1	3	1mx1_THA_A_1 PDB CREDO	0.550	0.244	0.506	0.010
Rv1915.1	3	3h52_486_C_4 PDB CREDO	0.636	0.139	0.506	0.010
Rv1915.1	3	1fj8_CER_B_500 PDB CREDO	0.549	0.246	0.505	0.010
Rv1915.1	3	3sv8_SV6_A_1 PDB CREDO	0.526	0.278	0.505	0.010
Rv1915.1	3	1g50_EST_A_600 PDB CREDO	0.504	0.311	0.504	0.010
Rv1915.1	3	4enh_FVX_A_602 PDB CREDO	0.624	0.151	0.504	0.010
Rv1915.1	3	3vri_1KX_A_301 PDB CREDO	0.525	0.280	0.504	0.010
Rv1915.1	5	1uob_PNN_A_1311 PDB CREDO	0.667	0.108	0.504	0.010
Rv1915.1	3	1udu_CIA_B_2003 PDB CREDO	0.570	0.217	0.503	0.010
Rv1915.1	3	2ydo_ADN_A_400 PDB CREDO	0.595	0.185	0.503	0.010
Rv1915.1	3	1mrl_DOL_A_300 PDB CREDO	0.545	0.251	0.502	0.011
Rv1915.1	3	2yja_EST_B_1550 PDB CREDO	0.502	0.315	0.502	0.011
Rv1915.1	3	3ols_EST_A_600 PDB CREDO	0.502	0.315	0.502	0.011
Rv1915.1	3	3uud_EST_A_600 PDB CREDO	0.502	0.315	0.502	0.011
Rv1915.1	5	2xkw_P1B_A_1478 PDB CREDO	0.528	0.276	0.501	0.011
Rv1915.1	3	3uud_EST_B_600 PDB CREDO	0.501	0.316	0.501	0.011
Rv1915.1	5	1fap_RAP_A_108 PDB CREDO	0.528	0.275	0.501	0.011
Rv1915.1	3	1bsx_T3_A_1 PDB CREDO	0.772	0.036	0.500	0.011
Rv1915.1	3	1bsx_T3_B_2 PDB CREDO	0.772	0.036	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
glyoxylatePubChem	0.943	74.0355
isocitratePubChem	0.935	192.124
acetyl-CoAPubChem	0.92	809.571
succinatePubChem	0.911	118.088
malatePubChem	0.903	134.087
D-malatePubChem	0.9	134.087
hydroxyl radicalsPubChem	0.9	17.0073
protiumPubChem	0.9	2.01576
cis-aconitatePubChem	0.9	174.108
acetyl coenzyme-APubChem	0.9	809.571
Co-APubChem	0.9	767.534
deuteriumPubChem	0.9	2.01588
D-isocitratePubChem	0.9	192.124
coenzyme APubChem	0.9	767.534
H(+)PubChem	0.9	2.01588