Rv1916

Tuberculist information
Gene nameaceAb
Protein functionProbable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2161.57
Molecular mass(da)44581.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 398
	  		  	1    MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPPWDCELAKT   60
			  	61   PEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNL  120
			  	121  SPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLAL  180
			  	181  ARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPR  240
			  	241  KLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGR  300
			  	301  TILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFT  360
			  	361  EVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 2 to 232  |  Coverage: 57% ICL Range: 31 to 233  |  Coverage: 50% 1
Number of amino acids : 398
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ICLPF004632-232
Mtb Structural Proteome models
Model Number1
Model nameRv1916
Template1F8M    APDBCREDO
Template coverage225_427
Template Identity(%)37.4
Model coverage(%)50.8
Normalized DOPE score0.679

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1916Gene nameConfidence Score
Rv1915aceAa0.999
Rv1837cglcB0.95
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glyoxylatePubChem0.93574.0355
isocitratePubChem0.922192.124
acetyl-CoAPubChem0.913809.571
D-malatePubChem0.9134.087
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
cis-aconitatePubChem0.9174.108
acetyl coenzyme-APubChem0.9809.571
malatePubChem0.9134.087
Co-APubChem0.9767.534
deuteriumPubChem0.92.01588
D-isocitratePubChem0.9192.124
succinatePubChem0.9118.088
coenzyme APubChem0.9767.534
H(+)PubChem0.92.01588