SInCRe - Rv3607c

Tuberculist information

Gene name	folB
Protein function	Probable dihydroneopterin aldolase FolB (DHNA)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	4048.74
Molecular mass(da)	14552.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 133

	  		  	1    MADRIELRGLTVHGRHGVYDHERVAGQRFVIDVTVWIDLAEAANSDDLADTYDYVRLASR   60
			  	61   AAEIVAGPPRKLIETVGAEIADHVMDDQRVHAVEVAVHKPQAPIPQTFDDVAVVIRRSRR  120
			  	121  GGRGWVVPAGGAV

Known structures in the PDB

	PDB ID	1NBU
	Total residue count	952
	Number of chains	8
	Method	X-RAY
	Resolution	1.6

	PDB ID	1Z9W
	Total residue count	133
	Number of chains	1
	Method	X-RAY
	Resolution	2.5

Number of amino acids : 133

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
FolB	PF02152	5-117

Mtb Structural Proteome models

Model Number	1
Model name	Rv3607c_1z9w_A
Template	1Z9W APDB CREDO
Template coverage	2_120
Template Identity(%)	100.0
Model coverage(%)	88.7
Normalized DOPE score	-1.202

Model Number	2
Model name	Rv3607c_1nbu_A
Template	1NBU APDB CREDO
Template coverage	2_119
Template Identity(%)	100.0
Model coverage(%)	88.0
Normalized DOPE score	-1.107

Model Number	3
Model name	Rv3607c
Template	1NBU APDB CREDO
Template coverage	2_119
Template Identity(%)	100.0
Model coverage(%)	88.0
Normalized DOPE score	-0.912

Structure Models from Chopin

Model Number	1
Profile	d.96.1.3 - 3.30.1130.10 Click for model details
zscore	22.28
Residue begin	1
Residue end	121

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3607c	Gene name	Confidence Score
Rv3606c	folK	0.999
Rv3608c	folP1	0.999
Rv3609c	folE	0.993
Rv1207	folP2	0.992
Rv2447c	folC	0.938
Rv2447c	folC	0.938
Rv0013	trpG	0.937

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
6-hydroxymethyl-7,8-dihydropterinPubChem	0.999	195.179
7,8-dihydroneopterinPubChem	0.995	255.231
glycolaldehydePubChem	0.974	60.052
hydroxyl radicalsPubChem	0.913	17.0073
phosphatePubChem	0.902	96.9872
adenosine triphosphatePubChem	0.9	507.181
dihydroneopterin monophosphatePubChem	0.9	335.211
H(+)PubChem	0.9	2.01588
adenosine monophosphatePubChem	0.9	347.221
7,8-dihydropterin pyrophosphatePubChem	0.9	355.138
protiumPubChem	0.9	2.01576
deuteriumPubChem	0.9	2.01588
neopterinPubChem	0.879	253.215
7,8-dihydromonapterinPubChem	0.816	255.231
folatePubChem	0.787	441.397