Rv3606c

Tuberculist information
Gene namefolK
Protein function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4048.18
Molecular mass(da)20731.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 188
	  		  	1    MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP   60
			  	61   TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP  120
			  	121  HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRH  180
			  	181  PVSRAPES

Known structures in the PDB
No Known structures
1 19 37 55 73 91 109 127 145 163 181 Range: 5 to 137  |  Coverage: 70% HPPK Range: 2 to 170  |  Coverage: 89% 1 Range: 1 to 186  |  Coverage: 98% 1
Number of amino acids : 188
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HPPKPF012885-137
Mtb Structural Proteome models
Model Number1
Model nameRv3606c
Template1F9Y    APDBCREDO
Template coverage1_158
Template Identity(%)29.1
Model coverage(%)88.9
Normalized DOPE score-0.883

Structure Models from Chopin
Model Number1
Profiled.58.30.1 - 3.30.70.560
Click for model details
zscore30.75
Residue begin1
Residue end186
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3606cGene nameConfidence Score
Rv3607cfolB0.999
Rv3608cfolP10.999
Rv1207folP20.999
Rv3609cfolE0.998
Rv2763cdfrA0.964
Rv2447cfolC0.937
Rv2447cfolC0.937
Rv3602cpanC0.927
Rv0013trpG0.925
Rv3610cftsH0.905
Rv3610cftsH0.905
Rv3610cftsH0.905
Rv3907cpcnA0.901
Rv3907cpcnA0.901
Rv3907cpcnA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
6-hydroxymethyl-7,8-dihydropterinPubChem0.988195.179
adenosine triphosphatePubChem0.958507.181
adenosine monophosphatePubChem0.958347.221
p-aminobenzoic acidPubChem0.934137.136
pyrophosphatePubChem0.928177.975
7,8-dihydroneopterinPubChem0.921255.231
7,8-dihydropterin pyrophosphatePubChem0.9355.138
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
dihydropteroatePubChem0.9314.299
glycolaldehydePubChem0.960.052
protiumPubChem0.92.01576
para-aminosalicylic acidPubChem0.8153.135
alpha,beta-methylene ATPPubChem0.755505.208
magnesiumPubChem0.75524.305