Rv3907c

Tuberculist information
Gene namepcnA
Protein functionProbable poly(A) polymerase PcnA (polynucleotide adenylyltransferase) (NTP polymerase) (RNA adenylating enzyme) (poly(A) polymerase)
Functional category(tuberculist)information pathways
Gene location(kb)4391.63
Molecular mass(da)53055.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 480
	  		  	1    VPEAVQEADLLTAAAVALNRHAALLRELGSVFAAAGHELYLVGGSVRDALLGRLSPDLDF   60
			  	61   TTDARPERVQEIVRPWADAVWDTGIEFGTVGVGKSDHRMEITTFRADSYDRVSRHPEVRF  120
			  	121  GDCLEGDLVRRDFTTNAMAVRVTATGPGEFLDPLGGLAALRAKVLDTPAAPSGSFGDDPL  180
			  	181  RMLRAARFVSQLGFAVAPRVRAAIEEMAPQLARISAERVAAELDKLLVGEDPAAGIDLMV  240
			  	241  QSGMGAVVLPEIGGMRMAIDEHHQHKDVYQHSLTVLRQAIALEDDGPDLVLRWAALLHDI  300
			  	301  GKPATRRHEPDGGVSFHHHEVVGAKMVRKRMRALKYSKQMIDDISQLVYLHLRFHGYGDG  360
			  	361  KWTDSAVRRYVTDAGALLPRLHKLVRADCTTRNKRRAARLQASYDRLEERIAELAAQEDL  420
			  	421  DRVRPDLDGNQIMAVLDIPAGPQVGEAWRYLKELRLERGPLSTEEATTELLSWWKSRGNR  480

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 39 to 166  |  Coverage: 26% PolyA_pol Range: 193 to 255  |  Coverage: 12% PolyA_pol_RNAbd Range: 268 to 418  |  Coverage: 31% HD Range: 25 to 478  |  Coverage: 94% 1 Range: 8 to 426  |  Coverage: 87% 1 Range: 8 to 163  |  Coverage: 32% 2 Range: 164 to 480  |  Coverage: 65% 3 Range: 162 to 400  |  Coverage: 49% 4
Number of amino acids : 480
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PolyA_polPF0174339-166
PolyA_pol_RNAbdPF12627193-255
HDPF01966268-418
Mtb Structural Proteome models
Model Number1
Model nameRv3907c
Template1MIW    APDBCREDO
Template coverage8_397
Template Identity(%)32.5
Model coverage(%)94.4
Normalized DOPE score0.779

Structure Models from Chopin
Model Number1
Profilea.173.1.1, d.218.1.4 - 1.10.3090.10, 3.30.460.10
Click for model details
zscore42.58
Residue begin8
Residue end426
Model Number2
Profiled.218.1.4
Click for model details
zscore38.71
Residue begin8
Residue end163
Model Number3
Profilea.173.1.1
Click for model details
zscore25.93
Residue begin164
Residue end480
Model Number4
Profile1.10.3090.10
Click for model details
zscore18.97
Residue begin162
Residue end400
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3907cGene nameConfidence Score
Rv3606cfolK0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions