Rv2357c

Tuberculist information
Gene nameglyS
Protein functionProbable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS)
Functional category(tuberculist)information pathways
Gene location(kb)2639.67
Molecular mass(da)52905.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 463
	  		  	1    VHHPVAPVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVVTG   60
			  	61   RDDVVGIDSSIILPREVWVASGHVDVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPN  120
			  	121  GLADIRDPETGEPGQWTQPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTT  180
			  	181  ARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPATAKEWHQYWIDNRLQW  240
			  	241  YIDLGIRRENLRLWEHPKDKLSHYSDRTVDIEYKFGFMGNPWGELEGVANRTDFDLSTHA  300
			  	301  RHSGVDLSFYDQINDVRYTPYVIEPAAGLTRSFMAFLIDAYTEDEAPNTKGGMDKRTVLR  360
			  	361  LDPRLAPVKAAVLPLSRHADLSPKARDLGAELRKCWNIDFDDAGAIGRRYRRQDEVGTPF  420
			  	421  CVTVDFDSLQDNAVTVRERDAMTQDRVAMSSVADYLAVRLKGS

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 45 to 278  |  Coverage: 50% tRNA-synt_2b Range: 369 to 459  |  Coverage: 19% HGTP_anticodon Range: 6 to 461  |  Coverage: 98% 1 Range: 354 to 463  |  Coverage: 23% 1
Number of amino acids : 463
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_2bPF0058745-278
HGTP_anticodonPF03129369-459
Mtb Structural Proteome models
Model Number1
Model nameRv2357c
Template1ATI    APDBCREDO
Template coverage2_504
Template Identity(%)47.6
Model coverage(%)98.3
Normalized DOPE score-0.205

Structure Models from Chopin
Model Number1
Profilec.51.1.1
Click for model details
zscore12.23
Residue begin354
Residue end463
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2357cGene nameConfidence Score
Rv1689tyrS0.982
Rv1689tyrS0.982
Rv1536ileS0.968
Rv1536ileS0.968
Rv2614cthrS0.952
Rv2614cthrS0.952
Rv2614cthrS0.952
Rv3598clysS0.946
Rv3598clysS0.946
Rv2992cgltS0.941
Rv2555calaS0.908
Rv2555calaS0.908
Rv2555calaS0.908
Rv2448cvalS0.901
Rv2448cvalS0.901
Rv2448cvalS0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.972507.181
polyglycinePubChem0.92475.0666
pyrophosphatePubChem0.9177.975
adenosine monophosphatePubChem0.9347.221
glycyl-adenylatePubChem0.758404.273