Rv2368c

Tuberculist information
Gene namephoH1
Protein functionProbable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2648.92
Molecular mass(da)37767.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 352
	  		  	1    VTSRETRAADAAGARQADAQVRSSIDVPPDLVVGLLGSADENLRALERTLSADLHVRGNA   60
			  	61   VTLCGEPADVALAERVISELIAIVASGQSLTPEVVRHSVAMLVGTGNESPAEVLTLDILS  120
			  	121  RRGKTIRPKTLNQKRYVDAIDANTIVFGIGPAGTGKTYLAMAKAVHALQTKQVTRIILTR  180
			  	181  PAVEAGERLGFLPGTLSEKIDPYLRPLYDALYDMMDPELIPKLMSAGVIEVAPLAYMRGR  240
			  	241  TLNDAFIVLDEAQNTTAEQMKMFLTRLGFGSKVVVTGDVTQIDLPGGARSGLRAAVDILE  300
			  	301  DIDDIHIAELTSVDVVRHRLVSEIVDAYARYEEPGSGLNRAARRASGARGRR

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 24 to 77  |  Coverage: 15% KH_1 Range: 125 to 329  |  Coverage: 57% PhoH Range: 91 to 302  |  Coverage: 59% 1 Range: 137 to 329  |  Coverage: 54% 1 Range: 22 to 77  |  Coverage: 15% 2
Number of amino acids : 352
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
KH_1PF0001324-77
PhoHPF02562125-329
Mtb Structural Proteome models
Model Number1
Model nameRv2368c
Template1W36    DPDBCREDO
Template coverage115_313
Template Identity(%)22.3
Model coverage(%)59.9
Normalized DOPE score0.417

Structure Models from Chopin
Model Number1
Profilec.37.1.17 - 3.40.50.300
Click for model details
zscore5.93
Residue begin137
Residue end329
Model Number2
Profile3.30.1900.10
Click for model details
zscore4.49
Residue begin22
Residue end77
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2368cGene nameConfidence Score
Rv2367cRv2367c0.995
Rv2366cRv2366c0.984
Rv2366cRv2366c0.984
Rv2366cRv2366c0.984
Rv2364cera0.92
Rv2364cera0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions