SInCRe - Rv2118c

Tuberculist information

Gene name	Rv2118c
Protein function	RNA methyltransferase
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2377.47
Molecular mass(da)	30090.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 280

	  		  	1    VSATGPFSIGERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAVIGLEQGSVVKSSNGA   60
			  	61   LFLVLRPLLVDYVMSMPRGPQVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTLSLLRA  120
			  	121  VGPAGQVISYEQRADHAEHARRNVSGCYGQPPDNWRLVVSDLADSELPDGSVDRAVLDML  180
			  	181  APWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRAKQCWTEPRAWETLQRGWNVVGL  240
			  	241  AVRPQHSMRGHTAFLVATRRLAPGAVAPAPLGRKREGRDG

Known structures in the PDB

	PDB ID	1I9G
	Total residue count	280
	Number of chains	1
	Method	X-RAY
	Resolution	1.98

Number of amino acids : 280

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
GCD14_N	PF14801	2-55
GCD14	PF08704	61-244

Mtb Structural Proteome models

Model Number	1
Model name	Rv2118c_1i9g_A
Template	1I9G APDB CREDO
Template coverage	4_267
Template Identity(%)	100.0
Model coverage(%)	93.9
Normalized DOPE score	-1.206

Model Number	2
Model name	Rv2118c
Template	1I9G APDB CREDO
Template coverage	4_267
Template Identity(%)	100.0
Model coverage(%)	93.9
Normalized DOPE score	-0.965

Structure Models from Chopin

Model Number	1
Profile	c.66.1.13 Click for model details
zscore	49.71
Residue begin	1
Residue end	270

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2118c	Gene name	Confidence Score
Rv1010	ksgA	0.913

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv2118c_1i9g_A	2	1t46_STI_A_3 PDB CREDO	0.661	0.114	0.661	0.001
Rv2118c_1i9g_A	4	1uwj_BAX_A_1723 PDB CREDO	0.649	0.125	0.613	0.002
Rv2118c_1i9g_A	2	1xkk_FMM_A_91 PDB CREDO	0.645	0.130	0.612	0.002
Rv2118c_1i9g_A	2	3sm2_478_A_126 PDB CREDO	0.677	0.099	0.611	0.002
Rv2118c_1i9g_A	4	1uwj_BAX_B_1723 PDB CREDO	0.622	0.154	0.604	0.002
Rv2118c_1i9g_A	4	3frq_ERY_A_195 PDB CREDO	0.604	0.175	0.604	0.002
Rv2118c_1i9g_A	2	3el9_DR7_A_100 PDB CREDO	0.616	0.160	0.600	0.002
Rv2118c_1i9g_A	2	1c6z_ROC_B_505 PDB CREDO	0.678	0.099	0.596	0.002
Rv2118c_1i9g_A	2	3ufn_ROC_A_401 PDB CREDO	0.609	0.168	0.593	0.002
Rv2118c_1i9g_A	4	1uwh_BAX_B_1723 PDB CREDO	0.648	0.126	0.593	0.002
Rv2118c_1i9g_A	2	1c6y_MK1_B_524 PDB CREDO	0.608	0.170	0.592	0.002
Rv2118c_1i9g_A	2	3cs9_NIL_C_600 PDB CREDO	0.591	0.190	0.591	0.002
Rv2118c_1i9g_A	4	1uwh_BAX_A_1723 PDB CREDO	0.647	0.128	0.591	0.002
Rv2118c_1i9g_A	2	3cs9_NIL_D_600 PDB CREDO	0.589	0.192	0.589	0.003
Rv2118c_1i9g_A	2	3gp0_NIL_A_1 PDB CREDO	0.601	0.178	0.585	0.003
Rv2118c_1i9g_A	4	3d91_REM_A_350 PDB CREDO	0.602	0.176	0.585	0.003
Rv2118c_1i9g_A	2	2qxs_RAL_B_600 PDB CREDO	0.616	0.160	0.584	0.003
Rv2118c_1i9g_A	2	2qxs_RAL_A_600 PDB CREDO	0.614	0.163	0.582	0.003
Rv2118c_1i9g_A	2	2fxd_DR7_A_102 PDB CREDO	0.597	0.182	0.581	0.003
Rv2118c_1i9g_A	2	1uwj_BAX_A_1723 PDB CREDO	0.666	0.109	0.581	0.003
Rv2118c_1i9g_A	4	3d91_REM_B_350 PDB CREDO	0.598	0.181	0.581	0.003
Rv2118c_1i9g_A	4	3b0w_DGX_A_1 PDB CREDO	0.597	0.182	0.580	0.003
Rv2118c_1i9g_A	2	3pww_ROC_A_1001 PDB CREDO	0.579	0.205	0.579	0.003
Rv2118c_1i9g_A	4	1z2b_VLB_C_800 PDB CREDO	0.614	0.163	0.578	0.003
Rv2118c_1i9g_A	4	3frq_ERY_B_195 PDB CREDO	0.672	0.104	0.578	0.003
Rv2118c_1i9g_A	2	1opj_STI_A_3 PDB CREDO	0.619	0.157	0.571	0.004
Rv2118c_1i9g_A	4	3b0w_DGX_B_1 PDB CREDO	0.619	0.157	0.568	0.004
Rv2118c_1i9g_A	2	1opj_STI_B_4 PDB CREDO	0.614	0.163	0.566	0.004
Rv2118c_1i9g_A	2	3ekq_ROC_A_100 PDB CREDO	0.596	0.183	0.565	0.004
Rv2118c_1i9g_A	2	1n49_RIT_B_301 PDB CREDO	0.609	0.169	0.561	0.004
Rv2118c_1i9g_A	2	2v0z_C41_O_1327 PDB CREDO	0.576	0.209	0.561	0.004
Rv2118c_1i9g_A	2	4asd_BAX_A_1500 PDB CREDO	0.700	0.081	0.560	0.004
Rv2118c_1i9g_A	4	1uob_PNN_A_1311 PDB CREDO	0.593	0.188	0.559	0.004
Rv2118c_1i9g_A	2	2pym_1UN_A_1001 PDB CREDO	0.635	0.140	0.558	0.004
Rv2118c_1i9g_A	2	3cs9_NIL_A_600 PDB CREDO	0.602	0.176	0.555	0.005
Rv2118c_1i9g_A	2	3k5v_STI_A_2 PDB CREDO	0.619	0.157	0.555	0.005
Rv2118c_1i9g_A	2	2pyn_1UN_A_1001 PDB CREDO	0.630	0.145	0.554	0.005
Rv2118c_1i9g_A	2	2qak_1UN_A_1001 PDB CREDO	0.629	0.146	0.554	0.005
Rv2118c_1i9g_A	2	3cs9_NIL_B_600 PDB CREDO	0.583	0.199	0.553	0.005
Rv2118c_1i9g_A	2	3pyy_STI_A_3 PDB CREDO	0.652	0.122	0.553	0.005
Rv2118c_1i9g_A	2	3spk_TPV_B_100 PDB CREDO	0.671	0.104	0.553	0.005
Rv2118c_1i9g_A	4	2nni_MTK_A_501 PDB CREDO	0.552	0.242	0.552	0.005
Rv2118c_1i9g_A	2	3oez_STI_A_601 PDB CREDO	0.650	0.125	0.551	0.005
Rv2118c_1i9g_A	2	3s56_ROC_A_201 PDB CREDO	0.565	0.224	0.550	0.005
Rv2118c_1i9g_A	2	2q63_1UN_A_1001 PDB CREDO	0.625	0.150	0.550	0.005
Rv2118c_1i9g_A	4	2hw2_RFP_A_1200 PDB CREDO	0.639	0.135	0.549	0.005
Rv2118c_1i9g_A	4	3bjw_SVR_E_503 PDB CREDO	0.650	0.125	0.549	0.005
Rv2118c_1i9g_A	2	2q64_1UN_B_1001 PDB CREDO	0.621	0.154	0.547	0.005
Rv2118c_1i9g_A	2	2hyy_STI_A_600 PDB CREDO	0.643	0.131	0.545	0.005
Rv2118c_1i9g_A	2	3mss_STI_B_1 PDB CREDO	0.642	0.132	0.544	0.005
Rv2118c_1i9g_A	2	3ms9_STI_B_1 PDB CREDO	0.642	0.133	0.544	0.006
Rv2118c_1i9g_A	2	3el4_ROC_A_100 PDB CREDO	0.681	0.096	0.544	0.006
Rv2118c_1i9g_A	2	1n49_RIT_D_401 PDB CREDO	0.641	0.133	0.544	0.006
Rv2118c_1i9g_A	2	3k5v_STI_B_2 PDB CREDO	0.641	0.133	0.544	0.006
Rv2118c_1i9g_A	2	2hyy_STI_D_600 PDB CREDO	0.641	0.134	0.543	0.006
Rv2118c_1i9g_A	2	3pyy_STI_B_4 PDB CREDO	0.641	0.134	0.543	0.006
Rv2118c_1i9g_A	4	4asd_BAX_A_1500 PDB CREDO	0.559	0.232	0.543	0.006
Rv2118c_1i9g_A	2	3mss_STI_A_1 PDB CREDO	0.640	0.134	0.542	0.006
Rv2118c_1i9g_A	2	3mss_STI_D_1 PDB CREDO	0.640	0.134	0.542	0.006
Rv2118c_1i9g_A	2	3ms9_STI_A_1 PDB CREDO	0.639	0.135	0.542	0.006
Rv2118c_1i9g_A	2	2hyy_STI_C_600 PDB CREDO	0.639	0.136	0.541	0.006
Rv2118c_1i9g_A	2	3mss_STI_C_1 PDB CREDO	0.638	0.136	0.541	0.006
Rv2118c_1i9g_A	2	1iep_STI_A_201 PDB CREDO	0.637	0.138	0.540	0.006
Rv2118c_1i9g_A	2	1uwj_BAX_B_1723 PDB CREDO	0.675	0.101	0.540	0.006
Rv2118c_1i9g_A	2	1iep_STI_B_202 PDB CREDO	0.636	0.138	0.539	0.006
Rv2118c_1i9g_A	2	3el0_1UN_A_201 PDB CREDO	0.601	0.178	0.539	0.006
Rv2118c_1i9g_A	2	3lzv_017_A_200 PDB CREDO	0.601	0.178	0.539	0.006
Rv2118c_1i9g_A	2	1uwh_BAX_A_1723 PDB CREDO	0.712	0.072	0.536	0.006
Rv2118c_1i9g_A	2	3gvu_STI_A_1001 PDB CREDO	0.633	0.142	0.536	0.006
Rv2118c_1i9g_A	2	3ogq_AB1_A_200 PDB CREDO	0.579	0.205	0.536	0.006
Rv2118c_1i9g_A	4	1t46_STI_A_3 PDB CREDO	0.650	0.124	0.535	0.006
Rv2118c_1i9g_A	2	1uwh_BAX_B_1723 PDB CREDO	0.711	0.073	0.535	0.006
Rv2118c_1i9g_A	2	2nni_MTK_A_501 PDB CREDO	0.650	0.125	0.535	0.006
Rv2118c_1i9g_A	2	3prs_RIT_A_1001 PDB CREDO	0.623	0.153	0.534	0.006
Rv2118c_1i9g_A	4	3tne_RIT_A_401 PDB CREDO	0.621	0.155	0.534	0.007
Rv2118c_1i9g_A	2	3so9_017_A_100 PDB CREDO	0.709	0.074	0.533	0.007
Rv2118c_1i9g_A	2	1rl8_RIT_A_9001 PDB CREDO	0.619	0.157	0.531	0.007
Rv2118c_1i9g_A	4	1hwk_117_B_1 PDB CREDO	0.546	0.250	0.530	0.007
Rv2118c_1i9g_A	2	2pl0_STI_A_200 PDB CREDO	0.682	0.096	0.529	0.007
Rv2118c_1i9g_A	2	3d91_REM_A_350 PDB CREDO	0.661	0.114	0.528	0.007
Rv2118c_1i9g_A	4	3tkd_CYZ_B_267 PDB CREDO	0.577	0.208	0.527	0.007
Rv2118c_1i9g_A	2	2hyy_STI_B_600 PDB CREDO	0.678	0.098	0.526	0.007
Rv2118c_1i9g_A	2	2v0z_C41_C_1328 PDB CREDO	0.583	0.200	0.526	0.007
Rv2118c_1i9g_A	4	1xkk_FMM_A_91 PDB CREDO	0.671	0.104	0.524	0.008
Rv2118c_1i9g_A	2	3d91_REM_B_350 PDB CREDO	0.655	0.120	0.524	0.008
Rv2118c_1i9g_A	2	3rgf_BAX_A_465 PDB CREDO	0.600	0.179	0.523	0.008
Rv2118c_1i9g_A	4	3tkd_CYZ_A_266 PDB CREDO	0.608	0.169	0.523	0.008
Rv2118c_1i9g_A	2	3tne_RIT_A_401 PDB CREDO	0.739	0.054	0.522	0.008
Rv2118c_1i9g_A	2	3ggu_017_B_201 PDB CREDO	0.550	0.244	0.522	0.008
Rv2118c_1i9g_A	4	1sa1_POD_B_700 PDB CREDO	0.537	0.262	0.522	0.008
Rv2118c_1i9g_A	2	1hsh_MK1_A_401 PDB CREDO	0.535	0.265	0.521	0.008
Rv2118c_1i9g_A	2	1hsh_MK1_C_402 PDB CREDO	0.535	0.265	0.521	0.008
Rv2118c_1i9g_A	2	3q70_RIT_A_2001 PDB CREDO	0.672	0.104	0.521	0.008
Rv2118c_1i9g_A	4	3h52_486_B_1 PDB CREDO	0.553	0.240	0.521	0.008
Rv2118c_1i9g_A	4	3jwq_VIA_D_901 PDB CREDO	0.714	0.071	0.520	0.008
Rv2118c_1i9g_A	2	3b0w_DGX_B_1 PDB CREDO	0.580	0.203	0.520	0.008
Rv2118c_1i9g_A	4	3ut5_LOC_B_502 PDB CREDO	0.567	0.220	0.519	0.008
Rv2118c_1i9g_A	4	2v0z_C41_O_1327 PDB CREDO	0.646	0.129	0.518	0.008
Rv2118c_1i9g_A	2	2nnk_ROC_A_401 PDB CREDO	0.633	0.142	0.517	0.008
Rv2118c_1i9g_A	2	1sa1_POD_B_700 PDB CREDO	0.646	0.128	0.516	0.008
Rv2118c_1i9g_A	4	1lhv_NOG_A_301 PDB CREDO	0.620	0.156	0.516	0.009
Rv2118c_1i9g_A	2	3bjw_SVR_E_503 PDB CREDO	0.530	0.273	0.516	0.009
Rv2118c_1i9g_A	4	1y0x_T44_X_500 PDB CREDO	0.564	0.225	0.516	0.009
Rv2118c_1i9g_A	2	2xkw_P1B_A_1478 PDB CREDO	0.558	0.234	0.516	0.009
Rv2118c_1i9g_A	2	3ndt_ROC_D_100 PDB CREDO	0.630	0.145	0.515	0.009
Rv2118c_1i9g_A	4	3bjw_SVR_B_501 PDB CREDO	0.659	0.115	0.515	0.009
Rv2118c_1i9g_A	2	2oiq_STI_A_1001 PDB CREDO	0.663	0.112	0.514	0.009
Rv2118c_1i9g_A	2	3kk6_CEL_A_701 PDB CREDO	0.542	0.256	0.514	0.009
Rv2118c_1i9g_A	2	1t7j_478_A_200 PDB CREDO	0.683	0.094	0.514	0.009
Rv2118c_1i9g_A	4	3h52_486_D_2 PDB CREDO	0.561	0.228	0.513	0.009
Rv2118c_1i9g_A	2	2y6o_1N1_A_1892 PDB CREDO	0.748	0.049	0.513	0.009
Rv2118c_1i9g_A	2	1sh9_RIT_B_301 PDB CREDO	0.526	0.278	0.512	0.009
Rv2118c_1i9g_A	2	2f80_017_B_301 PDB CREDO	0.581	0.202	0.511	0.009
Rv2118c_1i9g_A	4	3bjw_SVR_F_502 PDB CREDO	0.654	0.121	0.511	0.009
Rv2118c_1i9g_A	4	3bjw_SVR_H_504 PDB CREDO	0.654	0.121	0.511	0.009
Rv2118c_1i9g_A	4	1iep_STI_B_202 PDB CREDO	0.525	0.280	0.510	0.009
Rv2118c_1i9g_A	4	1fm6_BRL_X_504 PDB CREDO	0.612	0.164	0.510	0.009
Rv2118c_1i9g_A	2	3kk6_CEL_B_1701 PDB CREDO	0.538	0.262	0.509	0.009
Rv2118c_1i9g_A	4	1hwk_117_C_4 PDB CREDO	0.523	0.283	0.508	0.010
Rv2118c_1i9g_A	2	3heg_BAX_A_1 PDB CREDO	0.655	0.120	0.508	0.010
Rv2118c_1i9g_A	2	1hxb_ROC_A_100 PDB CREDO	0.577	0.207	0.508	0.010
Rv2118c_1i9g_A	4	1sa1_POD_D_701 PDB CREDO	0.539	0.260	0.508	0.010
Rv2118c_1i9g_A	4	1hwk_117_A_2 PDB CREDO	0.522	0.284	0.507	0.010
Rv2118c_1i9g_A	4	3ut5_LOC_D_502 PDB CREDO	0.590	0.191	0.507	0.010
Rv2118c_1i9g_A	4	2qxs_RAL_B_600 PDB CREDO	0.582	0.201	0.506	0.010
Rv2118c_1i9g_A	2	1ohr_1UN_A_201 PDB CREDO	0.519	0.289	0.506	0.010
Rv2118c_1i9g_A	2	1sa1_POD_D_701 PDB CREDO	0.652	0.123	0.506	0.010
Rv2118c_1i9g_A	4	2hyy_STI_B_600 PDB CREDO	0.536	0.264	0.505	0.010
Rv2118c_1i9g_A	4	3uvv_T3_A_501 PDB CREDO	0.607	0.171	0.505	0.010
Rv2118c_1i9g_A	2	3h52_486_B_1 PDB CREDO	0.650	0.124	0.505	0.010
Rv2118c_1i9g_A	4	3pyy_STI_A_3 PDB CREDO	0.519	0.289	0.504	0.010
Rv2118c_1i9g_A	4	1xzx_T3_X_500 PDB CREDO	0.606	0.172	0.504	0.010
Rv2118c_1i9g_A	4	3tne_RIT_B_401 PDB CREDO	0.587	0.195	0.504	0.010
Rv2118c_1i9g_A	4	2hyy_STI_A_600 PDB CREDO	0.519	0.289	0.504	0.010
Rv2118c_1i9g_A	4	3mss_STI_C_1 PDB CREDO	0.519	0.289	0.504	0.010
Rv2118c_1i9g_A	4	3vn2_TLS_A_501 PDB CREDO	0.568	0.219	0.504	0.010
Rv2118c_1i9g_A	2	3el5_1UN_B_201 PDB CREDO	0.558	0.233	0.503	0.010
Rv2118c_1i9g_A	4	2hyy_STI_C_600 PDB CREDO	0.518	0.291	0.503	0.010
Rv2118c_1i9g_A	4	3q70_RIT_A_2001 PDB CREDO	0.534	0.267	0.503	0.010
Rv2118c_1i9g_A	2	1sdv_MK1_B_902 PDB CREDO	0.503	0.314	0.503	0.010
Rv2118c_1i9g_A	2	1k6c_MK1_B_902 PDB CREDO	0.630	0.145	0.503	0.010
Rv2118c_1i9g_A	4	3nxu_RIT_A_600 PDB CREDO	0.579	0.205	0.503	0.010
Rv2118c_1i9g_A	4	1iep_STI_A_201 PDB CREDO	0.517	0.291	0.503	0.010
Rv2118c_1i9g_A	4	3k5v_STI_B_2 PDB CREDO	0.517	0.291	0.503	0.010
Rv2118c_1i9g_A	4	3ms9_STI_A_1 PDB CREDO	0.517	0.291	0.503	0.010
Rv2118c_1i9g_A	4	3mss_STI_A_1 PDB CREDO	0.517	0.291	0.503	0.010
Rv2118c_1i9g_A	4	2hyy_STI_D_600 PDB CREDO	0.517	0.292	0.502	0.011
Rv2118c_1i9g_A	4	3nxu_RIT_B_600 PDB CREDO	0.578	0.206	0.502	0.011
Rv2118c_1i9g_A	2	1hxw_RIT_B_301 PDB CREDO	0.529	0.274	0.502	0.011
Rv2118c_1i9g_A	4	3mss_STI_D_1 PDB CREDO	0.516	0.293	0.501	0.011
Rv2118c_1i9g_A	4	3pyy_STI_B_4 PDB CREDO	0.516	0.293	0.501	0.011
Rv2118c_1i9g_A	4	2y6o_1N1_A_1892 PDB CREDO	0.602	0.176	0.501	0.011
Rv2118c_1i9g_A	4	3ms9_STI_B_1 PDB CREDO	0.516	0.294	0.501	0.011
Rv2118c_1i9g_A	4	1hwl_FBI_D_3 PDB CREDO	0.531	0.271	0.501	0.011
Rv2118c_1i9g_A	4	3mss_STI_B_1 PDB CREDO	0.515	0.295	0.501	0.011
Rv2118c_1i9g_A	4	3oez_STI_A_601 PDB CREDO	0.515	0.295	0.501	0.011
Rv2118c_1i9g_A	4	3gvu_STI_A_1001 PDB CREDO	0.515	0.295	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
S-adenosyl-L-methioninePubChem	0.993	399.445
S-adenosylhomocysteinePubChem	0.849	384.411
N1-methyladenosinePubChem	0.836	281.268
1-methyladenosinePubChem	0.823	281.268
M1aPubChem	0.817	150.161
hydron sulfatePubChem	0.785	196.157
sulfatePubChem	0.785	96.0626