Rv2966c

Tuberculist information
Gene nameRv2966c
Protein functionPossible methyltransferase (methylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3318.9
Molecular mass(da)19788.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 188
	  		  	1    LTRIIGGVAGGRRIAVPPRGTRPTTDRVRESLFNIVTARRDLTGLAVLDLYAGSGALGLE   60
			  	61   ALSRGAASVLFVESDQRSAAVIARNIEALGLSGATLRRGAVAAVVAAGTTSPVDLVLADP  120
			  	121  PYNVDSADVDAILAALGTNGWTREGTVAVVERATTCAPLTWPEGWRRWPQRVYGDTRLEL  180
			  	181  AERLFANV

Known structures in the PDB
PDB ID3P9N
Total residue count189
Number of chains1
MethodX-RAY
Resolution1.9
1 19 37 55 73 91 109 127 145 163 181 Range: 2 to 182  |  Coverage: 95% Cons_hypoth95 Range: 2 to 186  |  Coverage: 97% 1 Range: 1 to 188  |  Coverage: 99% 1
Number of amino acids : 188
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Cons_hypoth95PF036022-182
Mtb Structural Proteome models
Model Number1
Model nameRv2966c
Template2FPO    APDBCREDO
Template coverage12_192
Template Identity(%)33.7
Model coverage(%)97.9
Normalized DOPE score-1.034

Structure Models from Chopin
Model Number1
Profilec.66.1.46 - 3.40.50.150
Click for model details
zscore36.96
Residue begin1
Residue end188
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2966cGene nameConfidence Score
Rv2965ckdtB0.917
Rv2372cRv2372c0.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-histidinePubChem0.9155.155
Se-adenosylselenomethioninePubChem0.9445.332
C05692PubChem0.9431.306
1-hydroxyphenanthrenePubChem0.9194.229
selenomethioninePubChem0.8196.106
SeMetPubChem0.8196.106