Rv1640c

Tuberculist information
Gene namelysX
Protein functionLysyl-tRNA synthetase 2 LysX
Functional category(tuberculist)information pathways
Gene location(kb)1848.52
Molecular mass(da)128208
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1172
	  		  	1    VGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQRAATPGISRLLGISSR   60
			  	61   SVTLTKPRSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSPLIRWIIKVPREFINDYLF  120
			  	121  NFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAVVNAAEIAAGGNTAAESFGEN  180
			  	181  LGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVVGIVASWGLVELFPGSLAP  240
			  	241  DERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFALIGAAIVLFLSQRADNALT  300
			  	301  GEDESAIRGLLDLYGKDDSLGYFATRRDKSVVFASSGRACITYRVEVGVCLASGDPVGDH  360
			  	361  RAWPQAVDAWLRLCQTYGWAPGVMGASSQGAQTYREAGLTALELGDEAILRPADFKLSGP  420
			  	421  EMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITRADSWRDTETERGFSMALGRLGD  480
			  	481  PADSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLMRRSPQSPNGTIELMVSELALHAE  540
			  	541  SLGITRISLNFAVFRAAFEQGAQLGAGPVARLWRGLLVFFSRWWQLETLYRSNMKYQPEW  600
			  	601  VPRYACYEDARVIPRVGVASVIAEGFLVLPFSRRNRVHTGHHPAVPERLAATGLLHHDGS  660
			  	661  APDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLEKLRSSGIDAFPVGRPPSHTVAQALAA  720
			  	721  DHQASVSVSGRIMRIRNYGGVLFAQLRDWSGEMQVLLDNSRLDQGCAADFNAATDLGDLV  780
			  	781  EMTGHMGASKTGTPSLIVSGWRLIGKCLRPLPNKWKGLLDPEARVRTRYLDLAVNAESRA  840
			  	841  LITARSSVLRAVRETLFAKGFVEVETPILQQLHGGATARPFVTHINTYSMDLFLRIAPEL  900
			  	901  YLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLEWIDGCRELIQNAA  960
			  	961  QAANGAPIAMRPRTDKGSDGTRHHLEPVDISGIWPVRTVHDAISEALGERIDADTGLTTL 1020
			  	1021 RKLCDAAGVPYRTQWDAGAVVLELYEHLVECRTEQPTFYIDFPTSVSPLTRPHRSKRGVA 1080
			  	1081 ERWDLVAWGIELGTAYSELTDPVEQRRRLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPP 1140
			  	1141 TGGLGMGIDRVVMLITGRSIRETLPFPLAKPH

Known structures in the PDB
No Known structures
1 118 235 352 469 586 703 820 937 1054 1171 Range: 308 to 607  |  Coverage: 25% DUF2156 Range: 726 to 804  |  Coverage: 6% tRNA_anti-codon Range: 820 to 1171  |  Coverage: 29% tRNA-synt_2 Range: 681 to 171  |  Coverage: -43% 1 Range: 675 to 1172  |  Coverage: 42% 1 Range: 820 to 1171  |  Coverage: 29% 2 Range: 726 to 804  |  Coverage: 6% 3 Range: 688 to 812  |  Coverage: 10% 4
Number of amino acids : 1172
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF2156PF09924308-607
tRNA_anti-codonPF01336726-804
tRNA-synt_2PF00152820-1171
Mtb Structural Proteome models
Model Number1
Model nameRv1640c
Template1BBU    APDBCREDO
Template coverage13_502
Template Identity(%)39.3
Model coverage(%)41.8
Normalized DOPE score0.141

Structure Models from Chopin
Model Number1
Profileb.40.4.1, d.104.1.1 - 2.40.50.140, 3.30.930.10
Click for model details
zscore45.17
Residue begin675
Residue end1172
Model Number2
Profile3.30.930.10
Click for model details
zscore27.74
Residue begin820
Residue end1171
Model Number3
Profileb.40.4.1 - 2.40.50.140
Click for model details
zscore18.72
Residue begin726
Residue end804
Model Number4
Profileb.40.4.1
Click for model details
zscore11.84
Residue begin688
Residue end812
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1640cGene nameConfidence Score
Rv3598clysS0.916
Rv3598clysS0.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-lysinePubChem0.908146.188
adenosine triphosphatePubChem0.901507.181
pyrophosphatePubChem0.9177.975
adenosine monophosphatePubChem0.9347.221