Rv0208c

Tuberculist information
Gene nameRv0208c
Protein functionHypothetical methlytransferase (methylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)248.115
Molecular mass(da)28546.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 263
	  		  	1    MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRETWERLWPELGLLALPQ   60
			  	61   SPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVDVIAVDVYRRGLAQLLCAI  120
			  	121  DKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDPWPKARHHKRRLLQPATMALI  180
			  	181  ADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDPDTELLPISVVRPATKYERKAQL  240
			  	241  GGGAVIELLWKKHGCSERDLKIR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 50 to 253  |  Coverage: 77% Methyltransf_4 Range: 52 to 251  |  Coverage: 75% 1 Range: 39 to 254  |  Coverage: 81% 1
Number of amino acids : 263
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Methyltransf_4PF0239050-253
Mtb Structural Proteome models
Model Number1
Model nameRv0208c
Template1YZH    APDBCREDO
Template coverage14_210
Template Identity(%)26.4
Model coverage(%)75.7
Normalized DOPE score-0.334

Structure Models from Chopin
Model Number1
Profilec.66.1.53
Click for model details
zscore37.07
Residue begin39
Residue end254
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0208cGene nameConfidence Score
Rv2906ctrmD0.965
Rv0204cRv0204c0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
S-adenosyl-L-methioninePubChem0.87399.445
glycerolPubChem0.75692.0938
polyethylene glycolPubChem0.70362.0678