Rv3419c

Tuberculist information
Gene namegcp
Protein functionProbable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3837.55
Molecular mass(da)35091
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 344
	  		  	1    MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEAL   60
			  	61   GPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLA  120
			  	121  ADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKVARLLGLGY  180
			  	181  PGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTAD  240
			  	241  IAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPS  300
			  	301  PRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQGQVR

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 28 to 313  |  Coverage: 82% Peptidase_M22 Range: 3 to 321  |  Coverage: 92% 1 Range: 3 to 322  |  Coverage: 92% 1
Number of amino acids : 344
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_M22PF0081428-313
Mtb Structural Proteome models
Model Number1
Model nameRv3419c
Template1HUX    APDBCREDO
Template coverage4_259
Template Identity(%)23.0
Model coverage(%)92.4
Normalized DOPE score1.017

Structure Models from Chopin
Model Number1
Profilec.55.1.14
Click for model details
zscore10.66
Residue begin3
Residue end322
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3419cGene nameConfidence Score
Rv3420crimI0.998
Rv3421cRv3421c0.998
Rv3422cRv3422c0.989
Rv3423calr0.941
Rv3423calr0.941
Rv2906ctrmD0.912
Rv0667rpoB0.901
Rv0667rpoB0.901
Rv0667rpoB0.901
Rv0667rpoB0.901
Rv0667rpoB0.901
Rv0667rpoB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
magnesiumPubChem0.79424.305
AMPPNPPubChem0.753506.196