Rv2535c

Tuberculist information
Gene namepepQ
Protein functionProbable cytoplasmic peptidase PepQ
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2859.3
Molecular mass(da)38758.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 372
	  		  	1    VTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADERDAVLATDGRY   60
			  	61   RTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLGFESHVVTVDGLDALAGALEGKNTE  120
			  	121  LVRASGTVESLREVKDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALM  180
			  	181  LDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDMTRTFVLG  240
			  	241  KAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHGLGHGVGL  300
			  	301  QIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVVAGGTPKMPETAGQTPE  360
			  	361  LLTRFPKELAIL

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 6 to 134  |  Coverage: 34% Creatinase_N Range: 141 to 346  |  Coverage: 55% Peptidase_M24 Range: 4 to 370  |  Coverage: 98% 1 Range: 1 to 372  |  Coverage: 99% 1 Range: 141 to 346  |  Coverage: 55% 2 Range: 1 to 372  |  Coverage: 99% 3 Range: 6 to 134  |  Coverage: 34% 4
Number of amino acids : 372
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Creatinase_NPF013216-134
Peptidase_M24PF00557141-346
Mtb Structural Proteome models
Model Number1
Model nameRv2535c
Template1WY2    APDBCREDO
Template coverage5_351
Template Identity(%)35.2
Model coverage(%)98.4
Normalized DOPE score-0.356

Structure Models from Chopin
Model Number1
Profilec.55.2.1, d.127.1.1 - 3.40.350.10, 3.90.230.10
Click for model details
zscore48.57
Residue begin1
Residue end372
Model Number2
Profiled.127.1.1
Click for model details
zscore42.88
Residue begin141
Residue end346
Model Number3
Profiled.127.1.1 - 3.90.230.10
Click for model details
zscore22.36
Residue begin1
Residue end372
Model Number4
Profilec.55.2.1
Click for model details
zscore11.96
Residue begin6
Residue end134
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2535cGene nameConfidence Score
Rv2534cefp0.984
Rv2534cefp0.984
Rv2534cefp0.984
Rv2533cnusB0.965
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
biocytinPubChem0.9372.483
glycerolPubChem0.72792.0938
zincPubChem0.71465.409