Rv1777

Tuberculist information
Gene namecyp144
Protein functionProbable cytochrome P450 144 Cyp144
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2010.66
Molecular mass(da)47186.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 434
	  		  	1    VRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAG   60
			  	61   SVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVL  120
			  	121  ATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPM  180
			  	181  MVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA  240
			  	241  DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV  300
			  	301  RANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFE  360
			  	361  APGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPS  420
			  	421  ILVRRIERLELAVQ

Known structures in the PDB
No Known structures
1 44 87 130 173 216 259 302 345 388 431 Range: 231 to 420  |  Coverage: 43% p450 Range: 38 to 433  |  Coverage: 91% 1 Range: 1 to 434  |  Coverage: 99% 1
Number of amino acids : 434
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067231-420
Mtb Structural Proteome models
Model Number1
Model nameRv1777
Template1Z8O    APDBCREDO
Template coverage5_402
Template Identity(%)27.5
Model coverage(%)91.0
Normalized DOPE score-0.469

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore37.61
Residue begin1
Residue end434
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1777Gene nameConfidence Score
Rv3545ccyp1250.947
Rv2276cyp1210.945
Rv3685ccyp1370.941
Rv0136cyp1380.941
Rv0327ccyp135A10.937
Rv3121cyp1410.937
Rv1666ccyp1390.936
Rv3059cyp1360.934
Rv0568cyp135B10.933
Rv2266cyp1240.933
Rv1785ccyp1430.932
Rv3518ccyp1420.927
Rv0778cyp1260.926
Rv1880ccyp1400.925
Rv1256ccyp1300.924
Rv2268ccyp1280.924
Rv0766ccyp1230.919
Rv3724Acut5a0.914
Rv1758cut10.912
Rv3084lipR0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11