Rv3059

Tuberculist information
Gene namecyp136
Protein functionProbable cytochrome P450 136 Cyp136
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3419.49
Molecular mass(da)56227.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 492
	  		  	1    MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPPPGSGLKPVVGD   60
			  	61   AGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVAALGPDAAQVIYSNRNKDY  120
			  	121  SQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDW  180
			  	181  VVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVP  240
			  	241  PFTWWRGLRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMIFL  300
			  	301  MMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQLESLDLVMNESI  360
			  	361  RLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIWTDPLTFDPERFTEPRN  420
			  	421  EHKRHRYAFTPFGGGVHKCIGMVFDQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPI  480
			  	481  PMDGMPIVLRPR

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 56 to 481  |  Coverage: 86% p450 Range: 67 to 492  |  Coverage: 86% 1 Range: 1 to 492  |  Coverage: 99% 1
Number of amino acids : 492
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006756-481
Mtb Structural Proteome models
Model Number1
Model nameRv3059
Template1X8V    APDBCREDO
Template coverage17_448
Template Identity(%)25.4
Model coverage(%)86.4
Normalized DOPE score-0.67

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore38.71
Residue begin1
Residue end492
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3059Gene nameConfidence Score
Rv1394ccyp1320.936
Rv1777cyp1440.934
Rv0327ccyp135A10.934
Rv0136cyp1380.933
Rv3685ccyp1370.93
Rv0568cyp135B10.93
Rv2268ccyp1280.93
Rv1666ccyp1390.927
Rv1880ccyp1400.926
Rv1785ccyp1430.922
Rv0766ccyp1230.922
Rv3545ccyp1250.913
Rv3518ccyp1420.91
Rv2266cyp1240.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00196DrugBankFluconazole
DB00251DrugBankTerconazole
DB00582DrugBankVoriconazole
DB01026DrugBankKetoconazole
DB01153DrugBankSertaconazole
DB01263DrugBankPosaconazole
DB04794DrugBankBifonazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11