Rv0766c

Tuberculist information
Gene namecyp123
Protein functionProbable cytochrome P450 123 Cyp123
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)858.864
Molecular mass(da)45421.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 402
	  		  	1    MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDS   60
			  	61   TALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLEL  120
			  	121  ARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALADAVLHREDGVADV  180
			  	181  PPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAG  240
			  	241  NETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLY  300
			  	301  DTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLARMEA  360
			  	361  RVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 186 to 397  |  Coverage: 52% p450 Range: 6 to 401  |  Coverage: 98% 1 Range: 1 to 402  |  Coverage: 99% 1
Number of amino acids : 402
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067186-397
Mtb Structural Proteome models
Model Number1
Model nameRv0766c
Template2C7X    APDBCREDO
Template coverage11_407
Template Identity(%)35.1
Model coverage(%)98.3
Normalized DOPE score-0.719

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore40.2
Residue begin1
Residue end402
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0766cGene nameConfidence Score
Rv0568cyp135B10.957
Rv2276cyp1210.937
Rv2268ccyp1280.936
Rv3518ccyp1420.935
Rv0778cyp1260.933
Rv0136cyp1380.931
Rv3685ccyp1370.931
Rv3121cyp1410.929
Rv0327ccyp135A10.926
Rv1785ccyp1430.926
Rv3059cyp1360.922
Rv1880ccyp1400.92
Rv1777cyp1440.919
Rv3545ccyp1250.919
Rv2266cyp1240.917
Rv1256ccyp1300.915
Rv0764ccyp510.908
Rv1666ccyp1390.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11