Rv3121

Tuberculist information
Gene namecyp141
Protein functionProbable cytochrome P450 141 Cyp141
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3486.51
Molecular mass(da)43730.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 400
	  		  	1    MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR   60
			  	61   FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD  120
			  	121  NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV  180
			  	181  SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP  240
			  	241  IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA  300
			  	301  LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF  360
			  	361  TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 164 to 386  |  Coverage: 55% p450 Range: 9 to 397  |  Coverage: 97% 1 Range: 1 to 400  |  Coverage: 99% 1
Number of amino acids : 400
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067164-386
Mtb Structural Proteome models
Model Number1
Model nameRv3121
Template1GWI    APDBCREDO
Template coverage10_405
Template Identity(%)31.1
Model coverage(%)96.8
Normalized DOPE score-1.066

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore43.51
Residue begin1
Residue end400
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3121Gene nameConfidence Score
Rv1880ccyp1400.949
Rv1256ccyp1300.949
Rv3518ccyp1420.94
Rv1777cyp1440.937
Rv3545ccyp1250.936
Rv1394ccyp1320.934
Rv2276cyp1210.933
Rv0766ccyp1230.929
Rv2268ccyp1280.929
Rv1785ccyp1430.928
Rv0778cyp1260.926
Rv2266cyp1240.925
Rv3685ccyp1370.91
Rv0136cyp1380.905
Rv3120Rv31200.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11