Rv3685c

Tuberculist information
Gene namecyp137
Protein functionProbable cytochrome P450 137 Cyp137
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4127.29
Molecular mass(da)52265.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 476
	  		  	1    MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGFRAAFAAAYAV   60
			  	61   AYLAGGERRMLRLIRRYGPIMTMPILSLGDVAIVSDSALAKEVFTAPTDVLLGGEGVGPA  120
			  	121  AAIYGSGSMFVQEEPEHLRRRKLLTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAML  180
			  	181  TVARSLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPA  240
			  	241  RARANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGEQLSDSEIRDDLITLVL  300
			  	301  AGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEAFTTAVINETLRVRPPAPLTARVA  360
			  	361  AQPLTIGGYRVEAGTRIVVHIIAINRSAEVYEHPHEFRPERFLGTRPQTYAWVPFGGGVK  420
			  	421  RCLGANFSMRELITVLHVLLREGEFTAVDDEPERIVRRSIMLVPRRGTRVRFRPAR

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 59 to 472  |  Coverage: 86% p450 Range: 45 to 476  |  Coverage: 90% 1 Range: 1 to 476  |  Coverage: 99% 1
Number of amino acids : 476
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006759-472
Mtb Structural Proteome models
Model Number1
Model nameRv3685c
Template1ZO4    APDBCREDO
Template coverage6_452
Template Identity(%)22.2
Model coverage(%)90.5
Normalized DOPE score-0.121

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore31.78
Residue begin1
Residue end476
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3685cGene nameConfidence Score
Rv1777cyp1440.941
Rv2268ccyp1280.94
Rv1394ccyp1320.937
Rv1880ccyp1400.936
Rv1785ccyp1430.934
Rv0766ccyp1230.931
Rv3059cyp1360.93
Rv0778cyp1260.928
Rv1666ccyp1390.925
Rv3545ccyp1250.925
Rv2266cyp1240.919
Rv0327ccyp135A10.915
Rv3518ccyp1420.913
Rv0568cyp135B10.913
Rv0136cyp1380.912
Rv3121cyp1410.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11