Rv0778

Tuberculist information
Gene namecyp126
Protein functionPossible cytochrome P450 126 Cyp126
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)871.431
Molecular mass(da)45954
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 414
	  		  	1    MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAET   60
			  	61   LEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIR  120
			  	121  RVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGF  180
			  	181  DFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSD  240
			  	241  AELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPS  300
			  	301  PSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFGQGV  360
			  	361  HYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 196 to 400  |  Coverage: 49% p450 Range: 6 to 412  |  Coverage: 98% 1 Range: 1 to 414  |  Coverage: 99% 1
Number of amino acids : 414
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067196-400
Mtb Structural Proteome models
Model Number1
Model nameRv0778
Template2C7X    APDBCREDO
Template coverage11_406
Template Identity(%)32.6
Model coverage(%)97.8
Normalized DOPE score-0.808

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore45.92
Residue begin1
Residue end414
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0778Gene nameConfidence Score
Rv0568cyp135B10.956
Rv2268ccyp1280.943
Rv0766ccyp1230.933
Rv3518ccyp1420.932
Rv2276cyp1210.929
Rv3685ccyp1370.928
Rv3121cyp1410.926
Rv1777cyp1440.926
Rv1785ccyp1430.924
Rv1880ccyp1400.923
Rv0136cyp1380.92
Rv1256ccyp1300.92
Rv0327ccyp135A10.913
Rv2266cyp1240.913
Rv3545ccyp1250.912
Rv1666ccyp1390.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11