Rv0568

Tuberculist information
Gene namecyp135B1
Protein functionPossible cytochrome P450 135B1 Cyp135B1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)659.45
Molecular mass(da)50687.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 472
	  		  	1    MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFTLHVAGFGHMVYLSDPA   60
			  	61   AIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAG  120
			  	121  PIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPRLLNVG  180
			  	181  PWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPDLAARTDTLAMLVRAAD  240
			  	241  EDGRTMTERELRDQLITLLVAGHDTTATGLSWALERLTRHPVTLAKAVQAADASAAGDPA  300
			  	301  GDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDP  360
			  	361  ERFDPDRMVGATLSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELSTTTTSGER  420
			  	421  PKLKHVIMVPHRGARIRVRATRDVSATSQATAQGAGCPAARGGGPSRAVGSQ

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 10 to 438  |  Coverage: 90% p450 Range: 11 to 442  |  Coverage: 91% 1 Range: 1 to 472  |  Coverage: 99% 1
Number of amino acids : 472
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006710-438
Mtb Structural Proteome models
Model Number1
Model nameRv0568
Template1ZO4    APDBCREDO
Template coverage6_452
Template Identity(%)20.8
Model coverage(%)91.3
Normalized DOPE score-0.28

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore40.06
Residue begin1
Residue end472
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0568Gene nameConfidence Score
Rv2268ccyp1280.962
Rv0766ccyp1230.957
Rv0778cyp1260.956
Rv3518ccyp1420.945
Rv1394ccyp1320.935
Rv1777cyp1440.933
Rv3059cyp1360.93
Rv1785ccyp1430.925
Rv1666ccyp1390.925
Rv1880ccyp1400.922
Rv0565cRv0565c0.918
Rv3685ccyp1370.913
Rv0136cyp1380.911
Rv0327ccyp135A10.909
Rv3545ccyp1250.909
Rv2266cyp1240.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00196DrugBankFluconazole
DB00251DrugBankTerconazole
DB00582DrugBankVoriconazole
DB01026DrugBankKetoconazole
DB01153DrugBankSertaconazole
DB01263DrugBankPosaconazole
DB04794DrugBankBifonazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
catecholPubChem0.903110.111
C16205PubChem0.9212.244
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11