Rv0565c

Tuberculist information
Gene nameRv0565c
Protein functionProbable monooxygenase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)656.01
Molecular mass(da)54525.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 486
	  		  	1    MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRS   60
			  	61   DSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDT  120
			  	121  WTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYTG  180
			  	181  KKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHL  240
			  	241  IVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLI  300
			  	301  PDADLYNAITSGRAEVVTDHIDHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISL  360
			  	361  DGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTR  420
			  	421  AAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEA  480
			  	481  MVFGAA

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 13 to 216  |  Coverage: 41% Pyr_redox_3 Range: 7 to 473  |  Coverage: 95% 1 Range: 13 to 216  |  Coverage: 41% 1 Range: 168 to 295  |  Coverage: 26% 2
Number of amino acids : 486
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_3PF1373813-216
Mtb Structural Proteome models
Model Number1
Model nameRv0565c
Template1W4X    APDBCREDO
Template coverage14_525
Template Identity(%)25.5
Model coverage(%)95.9
Normalized DOPE score0.205

Structure Models from Chopin
Model Number1
Profilec.3.1.6 - 3.50.50.60
Click for model details
zscore11.72
Residue begin13
Residue end216
Model Number2
Profilec.2.1.11
Click for model details
zscore9.74
Residue begin168
Residue end295
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0565cGene nameConfidence Score
Rv0892Rv08920.924
Rv0568cyp135B10.918
Rv0217clipW0.902
Rv2970clipN0.902
Rv2266cyp1240.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11