SInCRe - Rv0892

Tuberculist information

Gene name	Rv0892
Protein function	Probable monooxygenase
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	993.853
Molecular mass(da)	55038.9
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 495

	  		  	1    MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSR   60
			  	61   LYQYSFAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGRWVLRTD  120
			  	121  SGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGST  180
			  	181  GVQLVCGLAGVAGKVTMFQRTAQWVLPWPNPRYSKLARVFHRAFPCLGSLAYKAYSLSFE  240
			  	241  TFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRALTPDYEPMCKRLVMSGGFYRAIQRD  300
			  	301  DVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRIDDVWQ  360
			  	361  DGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEP  420
			  	421  KSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDGIPEVWPFAPAKHRAMLANLHPEEYDL  480
			  	481  RRYAAVRATSRPQSA

Known structures in the PDB

No Known structures

Number of amino acids : 495

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Pyr_redox_3	PF13738	9-205

Mtb Structural Proteome models

Model Number	1
Model name	Rv0892
Template	1W4X APDB CREDO
Template coverage	14_537
Template Identity(%)	29.8
Model coverage(%)	96.0
Normalized DOPE score	-0.611

Structure Models from Chopin

Model Number	1
Profile	c.3.1.6 - 3.50.50.60 Click for model details
zscore	8.07
Residue begin	9
Residue end	205

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0892	Gene name	Confidence Score
Rv1988	erm(37)	0.957
Rv3545c	cyp125	0.938
Rv0565c	Rv0565c	0.924

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
2,2-bis(4-hydroxyphenyl)-1-propanolPubChem	0.9	244.286
phenanthrenePubChem	0.9	178.229
2,6-dichlorohydroquinonePubChem	0.9	179.001
benzoquinonePubChem	0.9	108.095
1-hydroxyphenanthrenePubChem	0.9	194.229
monoterpenesPubChem	0.9	136.234
NSC96747PubChem	0.9	168.233
C07271PubChem	0.9	152.233
1-hydroxymethylnaphthalenePubChem	0.9	158.197
1,2-bis(4-hydroxyphenyl)-2-propanolPubChem	0.9	244.286
p-nitrophenolPubChem	0.9	139.109
2-hydroxymethylnaphthalenePubChem	0.9	158.197
2,5-dihydroxybenzoic acidPubChem	0.9	154.12
4-isopropenyl-1-methyl-7-oxabicyclo[4.1.0]heptanePubChem	0.9	152.233
bisphenol APubChem	0.9	228.286
1-(4'-hydroxyphenyl)ethanolPubChem	0.9	138.164
d-limonenePubChem	0.9	136.234
1,2,4-benzenetriolPubChem	0.9	126.11
(3R)-3-isopropenyl-6-oxoheptanoatePubChem	0.9	183.224
C0674PubChem	0.9	168.233
limonenePubChem	0.9	136.234