Rv2266

Tuberculist information
Gene namecyp124
Protein functionProbable cytochrome P450 124 Cyp124
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2540.1
Molecular mass(da)47825
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 428
	  		  	1    MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIEL   60
			  	61   PGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQR  120
			  	121  LRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMM  180
			  	181  GIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTS  240
			  	241  SLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGL  300
			  	301  APTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFD  360
			  	361  LARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGI  420
			  	421  KTLPVTWS

Known structures in the PDB
PDB ID2WM4
Total residue count435
Number of chains1
MethodX-RAY
Resolution2.11
PDB ID2WM5
Total residue count435
Number of chains1
MethodX-RAY
Resolution1.5
1 43 85 127 169 211 253 295 337 379 421 Range: 64 to 298  |  Coverage: 54% p450 Range: 300 to 398  |  Coverage: 22% p450 Range: 1 to 428  |  Coverage: 99% 1 Range: 23 to 428  |  Coverage: 94% 2 Range: 1 to 235  |  Coverage: 54% 1 Range: 64 to 298  |  Coverage: 54% 2 Range: 300 to 534  |  Coverage: 54% 3
Number of amino acids : 428
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006764-298
p450PF00067300-398
Mtb Structural Proteome models
Model Number1
Model nameRv2266_2wm5_A
Template2WM5    APDBCREDO
Template coverage1_428
Template Identity(%)100.0
Model coverage(%)99.8
Normalized DOPE score-1.91

Model Number2
Model nameRv2266
Template2C7X    APDBCREDO
Template coverage12_406
Template Identity(%)32.4
Model coverage(%)94.6
Normalized DOPE score-0.824

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore10.44
Residue begin1
Residue end235
Model Number2
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore10.44
Residue begin64
Residue end298
Model Number3
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore10.44
Residue begin300
Residue end534
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2266Gene nameConfidence Score
Rv2268ccyp1280.946
Rv1256ccyp1300.936
Rv1777cyp1440.933
Rv2276cyp1210.932
Rv3518ccyp1420.926
Rv3121cyp1410.925
Rv1880ccyp1400.925
Rv1785ccyp1430.924
Rv3545ccyp1250.919
Rv3685ccyp1370.919
Rv0766ccyp1230.917
Rv0136cyp1380.917
Rv0778cyp1260.913
Rv0327ccyp135A10.908
Rv3059cyp1360.908
Rv1666ccyp1390.907
Rv0568cyp135B10.907
Rv0565cRv0565c0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
calciumPubChem0.940.078
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11
trans-pinocarveolPubChem0.9152.233
VGJPubChem0.9311.522
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
phytanic acidPubChem0.9312.53