Rv0327c

Tuberculist information
Gene namecyp135A1
Protein functionPossible cytochrome P450 135A1 Cyp135A1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)392.696
Molecular mass(da)50010.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 449
	  		  	1    MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSLRVPPYADNLVVYTRP   60
			  	61   EHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHARMRSLLMPAFTRAALRGYR  120
			  	121  DMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRLQQIINI  180
			  	181  HPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRIDSDLTARTDVLSRLLQTK  240
			  	241  DTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHAPEIQSQVVWAAVGGDDGFL  300
			  	301  EAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNTSILLAHASEVSHPKPTEFRP  360
			  	361  SRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIFRRFTITAAGPSKGETPLVR  420
			  	421  NITTVPKHGAHLRLIPQRRLGGLGDSDPP

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 10 to 433  |  Coverage: 94% p450 Range: 6 to 438  |  Coverage: 96% 1 Range: 1 to 447  |  Coverage: 99% 1
Number of amino acids : 449
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006710-433
Mtb Structural Proteome models
Model Number1
Model nameRv0327c
Template1ZO4    APDBCREDO
Template coverage1_452
Template Identity(%)22.9
Model coverage(%)96.2
Normalized DOPE score-0.545

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore41.07
Residue begin1
Residue end447
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0327cGene nameConfidence Score
Rv1785ccyp1430.957
Rv1394ccyp1320.945
Rv1777cyp1440.937
Rv2268ccyp1280.935
Rv3059cyp1360.934
Rv1666ccyp1390.931
Rv0766ccyp1230.926
Rv1880ccyp1400.924
Rv0136cyp1380.916
Rv3685ccyp1370.915
Rv0778cyp1260.913
Rv0568cyp135B10.909
Rv3545ccyp1250.908
Rv2266cyp1240.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00196DrugBankFluconazole
DB00251DrugBankTerconazole
DB00582DrugBankVoriconazole
DB01026DrugBankKetoconazole
DB01153DrugBankSertaconazole
DB01263DrugBankPosaconazole
DB04794DrugBankBifonazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
catecholPubChem0.902110.111
C16205PubChem0.9212.244
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11