Rv1880c

Tuberculist information
Gene namecyp140
Protein functionProbable cytochrome P450 140 Cyp140
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2130.54
Molecular mass(da)48839.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 438
	  		  	1    VKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPFYDEVRSHGALVRNRAN   60
			  	61   YLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHT  120
			  	121  RYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILG  180
			  	181  VPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRGFDCWLEGHLQQLRHAPGDDLMS  240
			  	241  QLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNGIRMLLDTPEHLATLRQHP  300
			  	301  ELWPNTVEEILRLDSPVQLTARVACRDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHR  360
			  	361  FDIERPNAGRHLAFSTGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGAGSRRDTRVLR  420
			  	421  GWSTLPVTLGPARSMVSP

Known structures in the PDB
No Known structures
1 44 87 130 173 216 259 302 345 388 431 Range: 206 to 406  |  Coverage: 45% p450 Range: 29 to 430  |  Coverage: 91% 1 Range: 1 to 438  |  Coverage: 99% 1
Number of amino acids : 438
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067206-406
Mtb Structural Proteome models
Model Number1
Model nameRv1880c
Template1Z8O    APDBCREDO
Template coverage4_403
Template Identity(%)34.8
Model coverage(%)91.6
Normalized DOPE score-1.16

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore43.13
Residue begin1
Residue end438
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1880cGene nameConfidence Score
Rv3121cyp1410.949
Rv1256ccyp1300.946
Rv2276cyp1210.942
Rv3685ccyp1370.936
Rv0136cyp1380.933
Rv1785ccyp1430.93
Rv3059cyp1360.926
Rv1666ccyp1390.926
Rv3545ccyp1250.926
Rv1777cyp1440.925
Rv2266cyp1240.925
Rv0327ccyp135A10.924
Rv2268ccyp1280.924
Rv3518ccyp1420.923
Rv0778cyp1260.923
Rv0568cyp135B10.922
Rv0766ccyp1230.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11