Rv0136

Tuberculist information
Gene namecyp138
Protein functionProbable cytochrome P450 138 Cyp138
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)163.366
Molecular mass(da)49260.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 441
	  		  	1    MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVRRYGKAFTANILMYGRV   60
			  	61   VVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSM  120
			  	121  KNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPW  180
			  	181  VTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADPNFADRTDVLALM  240
			  	241  LRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLGWAFERLSRHPDVLAALVEEVDNGG  300
			  	301  HELRQAAILEVQRARTVIDFAARRVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQP  360
			  	361  DRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLETTTAAGER  420
			  	421  SHGRGVAFTPKDGGRVVMRRR

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 18 to 434  |  Coverage: 94% p450 Range: 15 to 441  |  Coverage: 96% 1 Range: 1 to 441  |  Coverage: 99% 1
Number of amino acids : 441
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006718-434
Mtb Structural Proteome models
Model Number1
Model nameRv0136
Template1Z10    APDBCREDO
Template coverage32_494
Template Identity(%)22.5
Model coverage(%)96.6
Normalized DOPE score-0.359

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore41.91
Residue begin1
Residue end441
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0136Gene nameConfidence Score
Rv1777cyp1440.941
Rv2268ccyp1280.94
Rv1785ccyp1430.933
Rv1880ccyp1400.933
Rv3059cyp1360.933
Rv0766ccyp1230.931
Rv1666ccyp1390.93
Rv1394ccyp1320.93
Rv3545ccyp1250.922
Rv0778cyp1260.92
Rv2266cyp1240.917
Rv0327ccyp135A10.916
Rv3685ccyp1370.912
Rv0568cyp135B10.911
Rv3121cyp1410.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00196DrugBankFluconazole
DB00251DrugBankTerconazole
DB00582DrugBankVoriconazole
DB01026DrugBankKetoconazole
DB01153DrugBankSertaconazole
DB01263DrugBankPosaconazole
DB04794DrugBankBifonazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11