Rv1785c

Tuberculist information
Gene namecyp143
Protein functionProbable cytochrome P450 143 Cyp143
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2023.45
Molecular mass(da)43541.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 393
	  		  	1    MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAAL   60
			  	61   RNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRHTVA  120
			  	121  MIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWKDAVIAMSDRPHPTEAD  180
			  	181  VAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAA  240
			  	241  VGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMTLPAG  300
			  	301  SPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHLARLELTLLVGEWL  360
			  	361  NQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 174 to 315  |  Coverage: 35% p450 Range: 320 to 393  |  Coverage: 18% p450 Range: 14 to 393  |  Coverage: 96% 1 Range: 1 to 142  |  Coverage: 35% 1 Range: 174 to 315  |  Coverage: 35% 2 Range: 320 to 461  |  Coverage: 35% 3
Number of amino acids : 393
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067174-315
p450PF00067320-393
Mtb Structural Proteome models
Model Number1
Model nameRv1785c
Template1T2B    APDBCREDO
Template coverage11_397
Template Identity(%)29.7
Model coverage(%)96.4
Normalized DOPE score-1.14

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore13.45
Residue begin1
Residue end142
Model Number2
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore13.45
Residue begin174
Residue end315
Model Number3
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore13.45
Residue begin320
Residue end461
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1785cGene nameConfidence Score
Rv0327ccyp135A10.957
Rv2276cyp1210.939
Rv1786Rv17860.936
Rv3685ccyp1370.934
Rv1666ccyp1390.933
Rv0136cyp1380.933
Rv1777cyp1440.932
Rv2268ccyp1280.932
Rv1880ccyp1400.93
Rv3545ccyp1250.929
Rv3121cyp1410.928
Rv3518ccyp1420.927
Rv0766ccyp1230.926
Rv0568cyp135B10.925
Rv2266cyp1240.924
Rv0778cyp1260.924
Rv3059cyp1360.922
Rv1256ccyp1300.921
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11