Rv2268c

Tuberculist information
Gene namecyp128
Protein functionProbable cytochrome P450 128 Cyp128
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2542.81
Molecular mass(da)53313.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 489
	  		  	1    MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSGGIPVATSMWR   60
			  	61   DAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDFDPFDPAIAADPYPHYREL  120
			  	121  LAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVTFSRGWLPFLPTSDPPAHTRM  180
			  	181  RKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPADVVSTVAAPMPMRAITSVLGVDG  240
			  	241  PDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGFRRLRALFTHRRDNGLLRECTVLGK  300
			  	301  LATHAEQGRLSDDELFFFAVLLLVAGYESTAHMISTLFLTLADYPDQLTLLAQQPDLIPS  360
			  	361  AIEEHLRFISPIQNICRTTRVDYSVGQAVIPAGSLVLLAWGAANRDPRQYEDPDVFRADR  420
			  	421  NPVGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDRIEVVEPPTWTTNANLRGLTRLR  480
			  	481  VAVTPRVAP

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 351 to 467  |  Coverage: 23% p450 Range: 97 to 485  |  Coverage: 79% 1
Number of amino acids : 489
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF00067351-467
Mtb Structural Proteome models
Model Number1
Model nameRv2268c
Template2C7X    APDBCREDO
Template coverage12_407
Template Identity(%)30.6
Model coverage(%)79.3
Normalized DOPE score-0.678

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2268cGene nameConfidence Score
Rv2267cRv2267c0.977
Rv0568cyp135B10.962
Rv2276cyp1210.954
Rv2266cyp1240.946
Rv3545ccyp1250.945
Rv0778cyp1260.943
Rv3685ccyp1370.94
Rv0136cyp1380.94
Rv1394ccyp1320.937
Rv0766ccyp1230.936
Rv0327ccyp135A10.935
Rv3518ccyp1420.935
Rv1256ccyp1300.934
Rv1785ccyp1430.932
Rv1666ccyp1390.931
Rv3059cyp1360.93
Rv3121cyp1410.929
Rv1777cyp1440.924
Rv1880ccyp1400.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C16205PubChem0.9212.244
catecholPubChem0.9110.111
myrtenolPubChem0.9152.233
trans-pinocarveolPubChem0.9152.233
monoterpenesPubChem0.9136.234
1,2,4-benzenetriolPubChem0.9126.11