Rv1394c

Tuberculist information
Gene namecyp132
Protein functionProbable cytochrome P450 132 Cyp132
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1569.58
Molecular mass(da)52229.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 461
	  		  	1    MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGSDITRFRCAGRRFVSIS   60
			  	61   HPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWARHRGALNSTFARRHLRGL  120
			  	121  VGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLR  180
			  	181  RAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLREMQEITLTLDRAINSVIDRRLAE  240
			  	241  PTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTANAMSWFWYLMALNPQARDHM  300
			  	301  LTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWIIAREAVDDDIIDGHRIRRGT  360
			  	361  TVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPTDRPRCAYLPFGGGRRICIGQSFALMEMV  420
			  	421  LMAAIMSQHFTFDLAPGYHVELEATLTLRPKHGVHVIGRRR

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 41 to 456  |  Coverage: 90% p450 Range: 10 to 461  |  Coverage: 97% 1 Range: 1 to 461  |  Coverage: 99% 1
Number of amino acids : 461
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
p450PF0006741-456
Mtb Structural Proteome models
Model Number1
Model nameRv1394c
Template1TQN    APDBCREDO
Template coverage38_496
Template Identity(%)23.0
Model coverage(%)97.8
Normalized DOPE score-0.302

Structure Models from Chopin
Model Number1
Profilea.104.1.1 - 1.10.630.10
Click for model details
zscore40.56
Residue begin1
Residue end461
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1394cGene nameConfidence Score
Rv1393cRv1393c0.949
Rv0327ccyp135A10.945
Rv3518ccyp1420.94
Rv1256ccyp1300.937
Rv3685ccyp1370.937
Rv2268ccyp1280.937
Rv3059cyp1360.936
Rv0568cyp135B10.935
Rv3121cyp1410.934
Rv0136cyp1380.93
Rv1666ccyp1390.928
Rv3545ccyp1250.913
Rv2276cyp1210.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cholesterolPubChem0.904386.654
catecholPubChem0.902110.111
C16205PubChem0.9212.244
hydroxyl radicalsPubChem0.917.0073
octanalPubChem0.9128.212
monoterpenesPubChem0.9136.234
NAD+PubChem0.9663.425
1,2,4-benzenetriolPubChem0.9126.11
H(+)PubChem0.92.01588
NADPPubChem0.9744.413
24S-hydroxycholesterolPubChem0.9402.653
octanolPubChem0.9130.228
n-octanePubChem0.9114.229
molecular oxygenPubChem0.931.9988
deuteriumPubChem0.92.01588
myrtenolPubChem0.9152.233
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
trans-pinocarveolPubChem0.9152.233
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
NADP(H)PubChem0.9745.421