Rv0018c

Tuberculist information
Gene namepstP
Protein functionPhosphoserine/threonine phosphatase PstP
Functional category(tuberculist)regulatory proteins
Gene location(kb)21.637
Molecular mass(da)53779.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 514
	  		  	1    VARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHL   60
			  	61   DDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSR  120
			  	121  GYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREA  180
			  	181  RAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD  240
			  	241  YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRR  300
			  	301  LAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCL  360
			  	361  SPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSL  420
			  	421  LPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAA  480
			  	481  PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA

Known structures in the PDB
PDB ID1TXO
Total residue count474
Number of chains2
MethodX-RAY
Resolution1.95
PDB ID2CM1
Total residue count260
Number of chains1
MethodX-RAY
Resolution2
1 52 103 154 205 256 307 358 409 460 511 Range: 16 to 218  |  Coverage: 39% PP2C_2 Range: 6 to 240  |  Coverage: 45% 1 Range: 6 to 238  |  Coverage: 45% 2 Range: 6 to 240  |  Coverage: 45% 1
Number of amino acids : 514
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PP2C_2PF1367216-218
Mtb Structural Proteome models
Model Number1
Model nameRv0018c_1txo_A
Template1TXO    APDBCREDO
Template coverage6_240
Template Identity(%)100.0
Model coverage(%)45.5
Normalized DOPE score-1.69

Model Number2
Model nameRv0018c
Template1TXO    APDBCREDO
Template coverage6_238
Template Identity(%)99.6
Model coverage(%)45.1
Normalized DOPE score-1.438

Structure Models from Chopin
Model Number1
Profiled.219.1.1 - 3.60.40.10
Click for model details
zscore51.13
Residue begin6
Residue end240
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0018cGene nameConfidence Score
Rv0014cpknB0.998
Rv0014cpknB0.998
Rv0015cpknA0.997
Rv0016cpbpA0.997
Rv0017crodA0.983
Rv2176pknL0.972
Rv1743pknE0.972
Rv1743pknE0.972
Rv1746pknF0.972
Rv1266cpknH0.97
Rv1266cpknH0.97
Rv0410cpknG0.94
Rv0019cfhaB0.936
Rv2088pknJ0.913
Rv2088pknJ0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3F)ccc2NC1=O
BRD4Cc1sc2c(C(=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n23)c4ccc(Cl)cc4)c1C
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3n4c(N)nnc14
BRD4Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4n12
BRD4CCC1=NCc2nnc(c3ccncc3)n2c4ccc(Cl)cc14
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccccc3Cl
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3N=C1NNC(=O)C
BRD4Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCc3ccccc3
BRD4CCOc1cccc(c1)c2c(C)onc2C
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3NC1=S
BRD4Cc1onc(C)c1c2ccc(OCCN3CCNCC3)c(c2)S(=O)(=O)NC4CCCC4
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3n4c(C)nnc14
BRD4CCC1=NCC(=S)Nc2ccc(Cl)cc12
BRD4Cc1onc(C)c1c2ccc(OCCCN3CCOCC3)c(c2)S(=O)(=O)NC4CCCC4
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCCO
BRD4COCCNS(=O)(=O)c1cc(ccc1C)c2c(C)onc2C
BRD4Cc1onc(C)c1c2ccc(O)c(c2)S(=O)(=O)NC3CCCC3
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(C)O
BRD4COc1ccc(NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C)cc1
BRD4COc1ccc(cc1S(=O)(=O)Nc2ccccc2)c3c(C)onc3C
BRD4CN1Cc2cc(ccc2NC1=O)S(=O)(=O)N3CCCC3
BRD4CN1Cc2cc(ccc2NC1=O)S(=O)(=O)Nc3ccccc3
BRD4CCNS(=O)(=O)c1cc(ccc1C)c2c(C)onc2C
BRD4CN1Cc2cc(Br)ccc2NC1=O
BRD4CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3ccc(OC)cc3n4c(C)nnc14
BRD4COc1ccccc1S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC(C)(C)C
BRD4COc1ccc(cc1S(=O)(=O)NCc2ccccc2)c3c(C)onc3C
BRD4CCOC(=O)c1ncn2c1[C@@H]3CCCN3C(=O)c4cc(OC)ccc24
BRD4COc1ccc(cc1)S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4COc1ccc(cc1S(=O)(=O)NC2CCCC2)c3c(C)onc3C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(C)cc3)ccc2NC1=O
BRD4CN1CCCC1=O
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3C)ccc2NC1=O
BRD4CN1Cc2cc(ccc2NC1=O)c3c(C)onc3C
BRD4CN1Cc2ccccc2NC1=O
BRD4Clc1ccc2N3C=NNC3=CN=C(c4ccccc4)c2c1
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCC3
BRD4Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4n12
BRD4Cc1nnc2C(NC(=O)OCc3ccccc3)N=C(c4ccccc4)c5ccccc5n12
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3cccc(Cl)c3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCOCC3
BRD4CCC1=NCc2nnc(C)n2c3ccc(Cl)cc13
BRD4CC(O)c1cccc(c1)c2c(C)onc2C
BRD4CCC1=NCc2nnc(c3ccccc3)n2c4ccc(Cl)cc14
BRD4Cc1onc(C)c1c2ccccc2
BRD4CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3cc(OC)ccc3n4c(C)nnc14
BRD4COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(=O)N)C(=O)CN(CCCCN)C(=O)CN(CCc1ccc(O)cc1)C(=O)CNCC(C)C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccc(Cl)cc3
BRD4CCC1=NCc2nnc(c3cccc(OC)c3)n2c4ccc(Cl)cc14
BRD4CC(=O)c1cccc(c1)c2c(C)onc2C
BRD4CC1CCc2ccccc2N1C(=O)C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3C(F)(F)F)ccc2NC1=O
BRD4CCC1=NCC(=O)Nc2ccc(Cl)cc12
BRD4CC(=O)Nc1ccc(O)cc1
BRD4CC(C)CN(CC(=O)N(CCCCN)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(=O)N)Cc1occc1)C(=O)CNCCCN2CCCC2=O
BRD4COc1ccc(cc1S(=O)(=O)NC2CCCNC2)c3c(C)onc3C
BRD4Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c4ccccc4)c5ccccc5n12
BRD4COc1ccc(cc1S(=O)(=O)NC2CCNCC2)c3c(C)onc3C
BRD4COc1cccc(c1)S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4CC(=O)c1cc(c2ccccn2)c3ccccn13
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCNCC3
BRD4CCOC(=O)c1cc(OCC)cc(c1)c2c(C)onc2C
BRD4CN1Cc2cc(ccc2N(C)C1=O)S(=O)(=O)N3CCOCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCNCC3
BRD4COc1ccccc1NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C
BRD4COc1ccc(cc1S(=O)(=O)N2CCNCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2cccc(c2)S(=O)(=O)NC3CC3
BRD4CCN(C1CCCC1)S(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCCc3ccccc3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCc3ccccc3
BRD4COc1ccc(cc1S(=O)(=O)Nc2ccccc2Cl)c3c(C)onc3C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(F)cc3Cl)ccc2NC1=O
BRD4COc1ccc(NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C)cc1
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2NC1=O
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(=O)O
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CC3
BRD4COc1cccc(NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C)c1
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3N4C(=O)NN=C14
BRD4COc1ccc(cc1S(=O)(=O)NC2CC2)c3c(C)onc3C
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(=O)C
BRD4Cc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4n12
BRD4COc1ccc(cc1S(=O)(=O)N2CCOCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCCCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCNC3
BRD4COc1ccccc1NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C
BRD4CCNS(=O)(=O)c1ccc2NC(=O)N(C)Cc2c1
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCCC3
BRD4CCC1=NCc2nnc(CC)n2c3ccc(Cl)cc13
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3)ccc2NC1=O
BRD4COc1ccc(cc1S(=O)(=O)N(C)C2CCCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccccc3
BRD4COc1cccc(NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C)c1
ClathrinBrc4ccc(C=c3sc(NS(=O)(=O)c1cccc2ccccc12)nc3=O)cc4
Clathrinc1cc2cc(cc3c2c(c1)C(=O)N(C3=O)Cc4ccc(cc4)N)S(=O)(=O)O
ZipAc1(c(cc2c(c1)N1\C(=C(/N2)\C)\C(=C(/C1=O)\CC(=O)O)\C)Cl)Cl
ZipAc1ccc2c(c1)c1c3n2C(C[C@@]2([C@@]3(N(CC1)CCC2)[H])[H])=O
ZipAc1(nc(oc1c1ccccc1)CCC(=O)O)c1ccccc1
ZipAc1cc(cc(n1)N1CCN(CC1)CCN)c1ccnc(n1)Nc1ccc(c(c1)Cl)C
ZipAc1ccc2c(c1)n(c1c2cnn2c1nnc2)C
ZipACc1ccc(Nc2nccc(n2)c3ccnc(c3)N4CCN(CCN)CC4)cc1Cl
ZipAc1ccc2c(c1)c1c(n2CCCN)c2c(CC1)cccc2
ZipAc1ccc2c(c1)cc(n2CCCN)C1CCCN(C1)C(c1ccc(cc1)c1ccccc1)=O
ZipAc1ccc2c(c1)cc1n2c2[n+](c3c1cccc3)CCC2
ZipAc1ccc2c(c1)c1c(n2CCCNS(=O)(=O)C(C)C)C2N(CC1=O)CCCC2
ZipAc1ccc2c(c1)c1c([nH]2)C2N(CC1=O)CCCC2
ZipAc1c(cc2c(c1)c(c1c(n2)ccc(c1)OC)NC(CCCO)C)Cl
ZipAc1ccc2c(c1)n(c1c2CCc2c1cccc2)CCCN
ZipAc1ccc2c(c1)cc(n2CCC(=O)NCCN1CCCC1)c1cccc(c1)Cl
ZipAc1ccc2c(c1)c(c([nH]2)c1ccccc1)c1cccc(c1)c1cccc(c1)C(=O)O
ZipAc1cc(cc(c1)N(C(C)=O)C)c1nnc2n1nc(cc2)c1ccccc1
ZipAc1ccc2c(c1)c1c(C2=O)nc2c(n1)cccn2
ZipAn1nnn(c1CC)C/C(=N/Nc1ccccn1)/C
ZipACN(C(=O)C)c1cccc(c1)c2nnc3ccc(nn23)c4ccccc4
ZipAc1ccc2c(c1)c(n[nH]2)c1ccncc1
ZipAc1ccc2c(c1)cc(nc2N)c1ncccc1
ZipAc1ccc2c(c1)[nH]c1c2[C@H](CO[C@]1(CC)CC(O)=O)C(=O)c1ccccc1
ZipAc1cc(nc(n1)c1ccncc1)c1sccc1
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerolPubChem0.93692.0938
manganesePubChem0.90854.938
SeMetPubChem0.9196.106
selenomethioninePubChem0.9196.106