Rv2088

Tuberculist information
Gene namepknJ
Protein functionTransmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
Functional category(tuberculist)regulatory proteins
Gene location(kb)2344.41
Molecular mass(da)61563.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 589
	  		  	1    VAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAAELSRDLDFRARFV   60
			  	61   READVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDALRAATMTTARAVYVIGEV  120
			  	121  AKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFGIARALGDTGLTSTGSVLATL  180
			  	181  AYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPPTVSD  240
			  	241  RVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDGWVPPSPAPHVISQG  300
			  	301  AVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTA  360
			  	361  VTMTSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFVGIQNLVA  420
			  	421  HEPMLQPQTPNGSINPAECWPAVGGGVPSAYDLGTVIGFYGLTIDEPPTGTAPNQVGQLI  480
			  	481  VAFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWRRPVELSTSVPEVVDGITTMVLTAQ  540
			  	541  GPVLRVREDHAIAAKNNVLVDVDIMTPDTSRGQQAVIGITNYILAKIPG

Known structures in the PDB
No Known structures
1 59 117 175 233 291 349 407 465 523 581 Range: 14 to 276  |  Coverage: 44% Pkinase Range: 392 to 587  |  Coverage: 33% PknH_C Range: 2 to 341  |  Coverage: 57% 1 Range: 14 to 276  |  Coverage: 44% 1 Range: 5 to 589  |  Coverage: 99% 2
Number of amino acids : 589
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PkinasePF0006914-276
PknH_CPF14032392-587
Mtb Structural Proteome models
Model Number1
Model nameRv2088
Template1KOB    APDBCREDO
Template coverage41_373
Template Identity(%)20.7
Model coverage(%)57.6
Normalized DOPE score0.311

Structure Models from Chopin
Model Number1
Profiled.144.1.7
Click for model details
zscore24.59
Residue begin14
Residue end276
Model Number2
Profiled.144.1.7
Click for model details
zscore12.45
Residue begin5
Residue end589
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2088Gene nameConfidence Score
Rv0018cpstP0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Plk1(PBD)CC(C)C1=CC(=O)C(C)=CC1=O
Plk1(PBD)CC(C)C1=CC(=N/O)C(C)=CC1=O
STITCH interactions  
No high confidence interactions