Rv2378c

Tuberculist information
Gene namembtG
Protein functionLysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2656.41
Molecular mass(da)46943.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 431
	  		  	1    MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLG   60
			  	61   TSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQ  120
			  	121  YLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALMITGPGQAEKSLLPGNPR  180
			  	181  VLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGE  240
			  	241  GFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVG  300
			  	301  RQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGGPLTA  360
			  	361  DRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHND  420
			  	421  TRRSGEHQSFR

Known structures in the PDB
No Known structures
1 44 87 130 173 216 259 302 345 388 431 Range: 6 to 238  |  Coverage: 53% Pyr_redox_3 Range: 4 to 418  |  Coverage: 96% 1
Number of amino acids : 431
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_3PF137386-238
Mtb Structural Proteome models
Model Number1
Model nameRv2378c
Template2CDU    APDBCREDO
Template coverage2_320
Template Identity(%)13.5
Model coverage(%)96.1
Normalized DOPE score1.168

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2378cGene nameConfidence Score
Rv2381cmbtD0.973
Rv2381cmbtD0.973
Rv2381cmbtD0.973
Rv2377cmbtH0.962
Rv2379cmbtF0.955
Rv2379cmbtF0.955
Rv2379cmbtF0.955
Rv2379cmbtF0.955
Rv2380cmbtE0.951
Rv2380cmbtE0.951
Rv2380cmbtE0.951
Rv2380cmbtE0.951
Rv2380cmbtE0.951
Rv2383cmbtB0.92
Rv2383cmbtB0.92
Rv2383cmbtB0.92
Rv2383cmbtB0.92
Rv2383cmbtB0.92
Rv2383cmbtB0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions